{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:51:52Z","timestamp":1753883512632,"version":"3.41.2"},"reference-count":28,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Stereotactic body radiation therapy (SBRT) is an effective option for patients with both early-stage and oligometastatic non\u2013small-cell lung cancer (NSCLC). However, data from Latin America are limited. Therefore, the aim of this study was to investigate the real-world outcomes of applying SBRT for lung lesions in a Brazilian institution. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> This study investigated a consecutive cohort of patients treated with SBRT for lung lesions (primary and metastasis). The study primary outcome was local control rates per lesion. Secondary outcomes included progression-free survival (PFS), overall survival (OS), and toxicity. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Between 2015 and 2019, a total of 216 patients received SBRT and were included in the study. The median follow-up was 24.5 months (5-70), primary NSCLC corresponded to 70% (n = 151) and nonprimary lung lesions to 30% (n = 65), respectively. Stage I NSCLC represented 56% (85 of 151) of the NSCLC cohort. The average number of fractions and total dose prescribed was 5 (3-10)\/59 Gy (50-62 Gy). For stage I NSCLC (all lesions treated with a biologically effective dose [10] &gt; 100 Gy), 2-year local control, OS, and PFS were 93.4%, 81.6%, and 80.7%, respectively. For stage IV lesions, if biologically effective dose (10) &gt; 100 Gy or &lt; 100 Gy, 2-year local control was 95.8\/86.4% ( P = .03), 2-year-OS was 81.6\/60.5% ( P = .006), and 2-year PFS was 38.9\/17.9% ( P = .10). Late toxicity was observed in 16.2% (n = 35) of the total cases. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Our results indicate that SBRT is effective (high local control and acceptable toxicity) for treating malignant lung lesions in a real-world scenario in Latin America. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.22.00061","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T20:59:30Z","timestamp":1668027570000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Real-World Evidence of Health Outcomes Related to Lung Stereotactic Body Radiation Therapy in Brazil"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-4331","authenticated-orcid":false,"given":"Lilian","family":"Faroni","sequence":"first","affiliation":[{"name":"Instituto COI de Pesquisa e Ensino, Rio de Janeiro, Brazil"},{"name":"Instituto D\u2019Or de Pesquisa e 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