{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:51:41Z","timestamp":1753883501137,"version":"3.41.2"},"reference-count":17,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Although cervical cancer is the second most commonly diagnosed cancer in Ethiopia, brachytherapy (BT) was not a component in patient treatment until 2015. The purpose of this study was to identify the patterns of utilization as well as to describe the practice of BT in Ethiopia. <\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p> A retrospective descriptive data analysis of 138 patients with cervical cancer treated with a curative potential using BT from 2015 to 2018 at Tikur Anbassa Specialized Hospital, which housed the only BT facility in Ethiopia during the study period. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> During the first 3-year period of BT service commencement, each year n = 37, n = 36, and n = 65 patients with cervical cancer were treated, respectively, with curative intention treatment. The median age of these 138 patients was 50 years (range, 22-75). All the patients were in International Federation of Gynecology and Obstetrics stage Ib\u2013IIIb group, and stage IIb (66.4%) was the predominant. Majority (79%) of the patients were treated primarily with radiotherapy (RT), while 21% received RT after surgery. More than half of these patients (62%) received a total RT dose of 82 Gy in equivalent dose in 2 Gy fractions (EQD2), while the rest received a dose ranging from 76 to 86 Gy. Concurrent cisplatin with RT was given only for 36% of the patients for undocumented reasons. The overall treatment time including both external-beam RT and BT was greater than 8 weeks in 21% of the patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> The utilization of BT service increased gradually and BT enabled the delivery of a higher RT dose to patients with cervical cancer (mostly stage IIB). However, there was protracted treatment duration and low concurrent chemotherapy utilization. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.22.00407","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T20:01:35Z","timestamp":1692388895000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of Brachytherapy for Patients With Cervical Cancer in Ethiopia: A 3-Year Practice Report"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-0170","authenticated-orcid":false,"given":"Yitbarek M.","family":"Kibret","sequence":"first","affiliation":[{"name":"Oncology Department, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia"},{"name":"Global Health Working Group, Martin-Luther-University Halle-Wittenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6270-0510","authenticated-orcid":false,"given":"Wondemagegnehu","family":"Tigeneh","sequence":"additional","affiliation":[{"name":"Oncology Department, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-4111","authenticated-orcid":false,"given":"Ahmedin","family":"Jemal","sequence":"additional","affiliation":[{"name":"Surveillance and Health Service Research, American Cancer Society, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva J.","family":"Kantelhardt","sequence":"additional","affiliation":[{"name":"Global Health Working Group, Martin-Luther-University Halle-Wittenberg, Germany"},{"name":"Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.16244"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0326"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2016.11.011"},{"key":"b5","first-page":"CD008285","volume":"2010","author":"Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC)","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.10.032"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2009.11.006"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12749"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2016.09.011"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.01.067"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90522-W"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00220-S"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.19.00129"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1200\/GO.20.00079"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401509"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4368"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00111-X"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181e6f321"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/GO.22.00407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T20:01:38Z","timestamp":1692388898000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/GO.22.00407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1200\/GO.22.00407"],"URL":"https:\/\/doi.org\/10.1200\/go.22.00407","relation":{},"ISSN":["2687-8941"],"issn-type":[{"type":"electronic","value":"2687-8941"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2022-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2200407"}}