{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:32:15Z","timestamp":1793925135303,"version":"4.8.0"},"reference-count":49,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Myelodysplastic syndromes (MDS) include a heterogeneous group of clonal bone marrow disorders characterized by ineffective hematopoiesis. They manifest as dysplasia in bone marrow hemopoietic elements associated with peripheral cytopenias with variable risk of AML transformation. <\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p> We analyzed retrospectively registry data collected prospectively from patients with primary MDS and patients with MDS\/myeloproliferative neoplasm (MPN) in the Jordan University Hospital between January 2007 and September 2021. The registry captured epidemiologic information such as date of diagnosis, age, gender, date of AML transformation, cytogenetics, MDS subtype, risk group according to Revised International Prognostic Scoring System, and survival. The registry also captured baseline ferritin, B12, and lactate dehydrogenase levels. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> A total of 112 patients with MDS and MDS\/MPN were included in the registry. Median age at diagnosis was 59 years. The male-to-female ratio was about 1.2. In a multivariate cox regression model, baseline serum ferritin significantly affected survival as patients with levels exceeding 1,000 \u03bcg\/L had a risk of death three times higher compared with those with &lt;1,000 \u03bcg\/L levels ( P &lt; .05). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> To our knowledge, our study is the first comprehensive study examining the epidemiology and prognostic factors in patients with MDS and patients with MDS\/MPN in Jordan. Our results show that MDS and MDS\/MPN epidemiology in Jordan is different compared with Western countries. Our results also show that baseline serum ferritin levels can be used as a prognostic marker for patients with MDS. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.23.00281","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T20:59:26Z","timestamp":1709240366000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Myelodysplastic Syndromes and Myelodysplastic Syndromes\/Myeloproliferative Neoplasms: A Real-World Experience From a Developing Country"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-948X","authenticated-orcid":true,"given":"Abdalla","family":"Awidi","sequence":"first","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"},{"name":"Jordan University Hospital, Amman, Jordan"},{"name":"Cell Therapy Center, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marah","family":"Alzu'bi","sequence":"additional","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2422-4061","authenticated-orcid":true,"given":"Nada","family":"Odeh","sequence":"additional","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-5102","authenticated-orcid":true,"given":"Jawad","family":"Alrawabdeh","sequence":"additional","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5341-8468","authenticated-orcid":true,"given":"Muntaser","family":"Al Zyoud","sequence":"additional","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan","family":"Hamadneh","sequence":"additional","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-3731","authenticated-orcid":true,"given":"Hisham","family":"Bawa'neh","sequence":"additional","affiliation":[{"name":"Al-Basheer Hospital, Ministry of Health, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Magableh","sequence":"additional","affiliation":[{"name":"Al-Basheer Hospital, Ministry of Health, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Alshorman","sequence":"additional","affiliation":[{"name":"Jordan University Hospital, Amman, Jordan"},{"name":"Al-Basheer Hospital, Ministry of Health, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feras","family":"Al-Fararjeh","sequence":"additional","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"},{"name":"Jordan University Hospital, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Aladily","sequence":"additional","affiliation":[{"name":"Medical School, University of Jordan, Amman, Jordan"},{"name":"Jordan University Hospital, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-8160","authenticated-orcid":true,"given":"Amer M.","family":"Zeidan","sequence":"additional","affiliation":[{"name":"Yale Cancer Center and Smilow Cancer Hospital, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22570"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0089-x"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.4065\/81.1.104"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2079"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3321"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013343"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-553800"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403562"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.01.002"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023109"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-784116"},{"key":"b14","first-page":"411","volume":"10","author":"Poggiali E","year":"2012","journal-title":"Blood Transfus"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.2217\/cer.15.20"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14621"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.04.006"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000314"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030481"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1159\/000226286"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.04.014"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1712-6"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140042"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2018.02.002"},{"key":"b25","first-page":"39","volume":"15","author":"AlMozain N","year":"2022","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2018.09.001"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0040"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2016.1277006"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2005.07.005"},{"key":"b30","first-page":"112","volume":"6","author":"Abyad A","year":"2021","journal-title":"Int J Ageing Developing Countries"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.04.004"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.7150\/jca.28220"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17534"},{"key":"b34","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20010082"},{"key":"b35","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.03.020"},{"key":"b36","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e19036"},{"key":"b37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179016"},{"key":"b38","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23454"},{"key":"b39","doi-asserted-by":"publisher","DOI":"10.1038\/srep10181"},{"key":"b40","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.08.005"},{"key":"b41","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.2842.2842"},{"key":"b42","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000942"},{"key":"b43","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-115928"},{"key":"b44","doi-asserted-by":"publisher","DOI":"10.15406\/htij.2021.09.00257"},{"key":"b45","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2013.814456"},{"key":"b46","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2018.03.002"},{"key":"b47","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3539-7"},{"key":"b48","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030895"},{"key":"b49","doi-asserted-by":"publisher","DOI":"10.1177\/2040620720966121"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/GO.23.00281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T13:59:33Z","timestamp":1709733573000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/GO.23.00281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1200\/GO.23.00281"],"URL":"https:\/\/doi.org\/10.1200\/go.23.00281","relation":{},"ISSN":["2687-8941"],"issn-type":[{"value":"2687-8941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2300281"}}