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A panel composed of 41 head and neck cancer experts systematically worked according to a modified Delphi process on (1) document compilation of evidence-based answers to different questions contextualized by resource availability and oncologic benefit regarding Latin America (region of limited resources and\/or without access to all necessary health care system infrastructure), (2) revision of the answers and the classification of levels of evidence and degrees of recommendations of all recommendations, (3) validation of the consensus through two rounds of online surveys, and (4) manuscript composition. The consensus consists of 12 sections: Head and neck cancer staging, Histopathologic evaluation of head and neck cancer, Head and neck surgery\u2014oral cavity, Clinical oncology\u2014oral cavity, Head and neck surgery\u2014oropharynx, Clinical oncology\u2014oropharynx, Head and neck surgery\u2014larynx, Head and neck surgery\u2014larynx\/hypopharynx, Clinical oncology\u2014larynx\/hypopharynx, Clinical oncology\u2014recurrent and metastatic head and neck cancer, Head and neck surgery\u2014reconstruction and rehabilitation, and Radiation therapy. The present consensus established 48 recommendations on HNSCC patient care considering the availability of resources and focusing on oncologic benefit. These recommendations could also be used to formulate strategies in other regions like Latin America countries.<\/jats:p>","DOI":"10.1200\/go.23.00343","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T15:59:28Z","timestamp":1712851168000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":16,"title":["Latin American Consensus on the Treatment of Head and Neck Cancer"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-8208","authenticated-orcid":false,"given":"Leandro Luongo","family":"Matos","sequence":"first","affiliation":[{"name":"Head and Neck Surgery, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo (Icesp HCFMUSP), S\u00e3o Paulo, Brazil"},{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein, S\u00e3o Paulo, 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