{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:20:55Z","timestamp":1778707255149,"version":"3.51.4"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Genetic cancer risk assessment (GCRA) provides pathogenic variant (PV) carriers with the invaluable opportunity to undertake timely cancer risk-reducing (RR) measures and initiate cascade testing (CT). This study describes the uptake of these strategies and the related barriers among breast cancer\u2013associated germline PV carriers in Mexico. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> Carriers who were at least 6 months after disclosure of genetic test results at two GCRA referral centers were invited to answer a survey assessing sociodemographic characteristics, awareness of their carrier status and its implications, uptake of RR measures according to international guidelines by PV, CT initiation, and associated challenges. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Of the eligible carriers, 246\/384 (64%) answered the survey (median age: 44 years). Most were female (88%), married\/in domestic partnership (66%), and had personal breast\/ovarian cancer history (61%). PVs included BRCA1\/ 2 (75%), CHEK2 (10%), PALB2 (5%), ATM (5%), NF1 (2%), RAD51C (2%), PTEN (1%), and TP53 (1%). Most (87%) participants were aware of their carrier status. When recommended, 37% underwent RR bilateral mastectomy, 48% RR oophorectomy, 70% annual mammogram, and 20% breast magnetic resonance imaging. Challenges hindering the uptake of RR measures included financial limitations (67%), lack of recommendation by their physician (35%), and fear (24%). Nearly all (98%) claimed sharing their results with their relatives. CT was initiated in 63% of families and was associated with carriers being married\/in domestic partnership ( P = .04) and believing GCRA was useful ( P &lt; .001). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Despite the resource-constrained setting, relevant rates of RR measures and CT were observed. Targeted interventions to reduce out-of-pocket expenses and improve patient-physician communication and patients' understanding on carrier status are warranted to enhance the overall benefit of GCRA and ultimately improve the provision of patient-centered care to both carriers and their at-risk relatives. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.23.00417","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T19:59:20Z","timestamp":1713470360000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Uptake of Risk-Reducing Measures, Cascade Testing, and Related Challenges Among Carriers of Breast Cancer\u2013Associated Germline Pathogenic Variants in Mexico"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4723-1837","authenticated-orcid":true,"given":"Fernanda","family":"Mesa-Chavez","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine 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