{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:53:51Z","timestamp":1784238831348,"version":"3.55.0"},"reference-count":32,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Prevention of chemotherapy-induced nausea and vomiting with currently recommended NK1 receptor antagonist\u2013based triplet during carboplatin (AUC \u22654) chemotherapy appears inadequate. A comparative study between olanzapine and NK1 receptor antagonist\u2013based combination is lacking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>This was a single-center, phase III, prospective randomized, double-blind, placebo-controlled superiority study comparing olanzapine (olanzapine, ondansetron, dexamethasone [OOD]-experimental arm) with fosaprepitant (fosaprepitant, ondansetron, dexamethasone [FOD]-standard arm) in combination with ondansetron and dexamethasone among chemotherapy-na\u00efve patients (age \u226518 years) receiving carboplatin (AUC \u22654) during the first cycle of single-day chemotherapy. The OOD arm received olanzapine 5 mg per oral once daily (day 1-4), ondansetron 8 mg with dexametahsone 12 mg intravenous (IV) once daily (20 mg with paclitaxel; day 1), and matching placebo for fosaprepitant (day 1). The FOD arm received fosaprepitant 150 mg IV once daily, with the combination (day 1) and matching placebo for olanzapine (days 1-4). The primary outcome was no nausea during the overall period (0-120 hours).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Between April 2021 and August 2022, a total of 195 patients were evaluable. The proportion of patients without nausea (0 as per Edmonton Symptom Assessment System scale) in OOD versus FOD arms was 44.1% versus 34.4% (\n              <jats:italic>P<\/jats:italic>\n              = .19) in the overall period (0-120 hours). Complete response rates and total control rates were also similar in both arms. One patient had grade 3 sedation in the olanzapine arm.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Olanzapine, in comparison with NK1 antagonist, is not superior for nausea control during carboplatin-induced emesis. It may act as an effective oral alternative for prevention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go.24.00166","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T20:00:04Z","timestamp":1742846404000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Olanzapine Versus NK1 Receptor Antagonist for Prevention of Carboplatin-Induced (AUC \u22654) Emesis: A Phase III, Double-Blind, Placebo-Controlled Randomized Trial From India"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3441-0609","authenticated-orcid":false,"given":"Sneh","family":"Bhargave","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-5449","authenticated-orcid":true,"given":"Vinod","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, National Cancer Institute, AIIMS\u2014 Jhajjar Campus, All India Institute of Medical Sciences, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-8363","authenticated-orcid":true,"given":"Babita","family":"Kataria","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, National Cancer Institute, AIIMS\u2014 Jhajjar Campus, All India Institute of Medical Sciences, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-8408","authenticated-orcid":true,"given":"Atul","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepam","family":"Pushpam","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-5426","authenticated-orcid":true,"given":"Aparna","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, National Cancer Institute, AIIMS\u2014 Jhajjar Campus, All India Institute of Medical Sciences, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-6254","authenticated-orcid":true,"given":"Raja","family":"Pramanik","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-8559","authenticated-orcid":true,"given":"Prabhat S.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-724X","authenticated-orcid":true,"given":"Ranjit. 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