{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:08:20Z","timestamp":1793243300402,"version":"4.5.0"},"reference-count":94,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"24","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2025,8,20]]},"abstract":"<jats:p>\n                    Despite significant improvements in survival of patients with multiple myeloma (MM), outcomes remain heterogeneous, and a significant proportion of patients experience suboptimal outcomes. Importantly, traditional prognostic factors based on data from patients treated with older therapies no longer capture prognosis accurately in the contemporary era of novel triplet or quadruplet therapies. Therefore, risk stratification requires refinement in the context of available and investigational treatment options in routine practice and clinical trials, respectively. The current identification of high-risk MM (HRMM) in routine practice is based on the Revised International Staging System, which stratifies patients using a combination of widely available serum biomarkers and chromosomal abnormalities assessed via fluorescence in situ hybridization. In recent years, a substantial body of evidence concerning additional clinical, biological, and molecular\/genomic prognostic factors has accumulated, along with new MM risk stratification tools and consensus reports. The International Myeloma Society, along with the International Myeloma Working Group, convened an Expert Panel with the primary aim of revisiting the definition of HRMM and formulating a practical and data-driven consensus definition, based on new evidence from molecular\/genomic assays, updated clinical data, and contemporary risk stratification concepts. The Panel proposes the following Consensus Genomic Staging (CGS) of HRMM which relies upon the presence of at least one of these abnormalities: (1) del(17p), with a cutoff of &gt;20% clonal fraction, and\/or\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    mutation; (2) an IgH translocation including t(4;14), t(14;16), or t(14;20) along with 1q+ and\/or del(1p32); (3) monoallelic del(1p32) along with 1q+ or biallelic del(1p32); or (4) \u03b22 microglobulin \u22655.5 mg\/L with normal creatinine (&lt;1.2 mg\/dL).\n                  <\/jats:p>","DOI":"10.1200\/jco-24-01893","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T15:59:08Z","timestamp":1749484748000},"page":"2739-2751","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":207,"title":["International Myeloma Society\/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma"],"prefix":"10.1200","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3050-0140","authenticated-orcid":true,"given":"Herv\u00e9","family":"Avet-Loiseau","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Genomique du My\u00e9lome, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Cancer Center of Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-2393","authenticated-orcid":true,"given":"Faith E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Perlmutter Cancer Center, NYU Langone Health, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-5682","authenticated-orcid":true,"given":"Mehmet K.","family":"Samur","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-6106","authenticated-orcid":true,"given":"Jill","family":"Corre","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Genomique du My\u00e9lome, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University Cancer Center of Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1711-6996","authenticated-orcid":true,"given":"Mattia","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Division of Hematology, AOU Citt\u00e0 della Salute e della Scienza di Torino, Torino, Italy"},{"name":"University of Torino and Department of Molecular Biotechnology and Health Sciences, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3677-4804","authenticated-orcid":true,"given":"Martin F.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom"},{"name":"Department of Haematology, The Royal Marsden Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-6922","authenticated-orcid":true,"given":"Marc S.","family":"Raab","sequence":"additional","affiliation":[{"name":"Department of Medicine V, Heidelberg Myeloma Center, University Hospital and Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-3234","authenticated-orcid":true,"given":"Niels","family":"Weinhold","sequence":"additional","affiliation":[{"name":"Department of Medicine V, Heidelberg Myeloma Center, University Hospital and Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-9510","authenticated-orcid":true,"given":"Norma C.","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda, Hospital Universitario de Salamanca, (HUSA\/IBSAL), Centro de Investigaci\u00f3n del C\u00e1ncer-IBMCC (CSIC\/USAL), CIBERONC, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-3815","authenticated-orcid":true,"given":"Bruno","family":"Paiva","sequence":"additional","affiliation":[{"name":"Cancer Center Cl\u00ednica Universidad de Navarra (CCUN), Centro de Investigaci\u00f3n M\u00e9dica Aplicada (CIMA LAB Diagnostics), IDISNA, CIBERONC, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Neri","sequence":"additional","affiliation":[{"name":"Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-6614","authenticated-orcid":true,"given":"Katja","family":"Weisel","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-1620","authenticated-orcid":true,"given":"Francesco","family":"Maura","sequence":"additional","affiliation":[{"name":"Division of Myeloma, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-6254","authenticated-orcid":true,"given":"Brian A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, School of Medicine, Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-5449","authenticated-orcid":true,"given":"Mark","family":"Bustoros","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Joan and Sanford I. 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