{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:46:42Z","timestamp":1792601202770,"version":"4.5.0"},"reference-count":8,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"19","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    In the phase III CodeBreaK 300 study, sotorasib 960 mg-panitumumab significantly prolonged progression-free survival (PFS) versus investigator's choice (trifluridine\/tipiracil or regorafenib) in patients with\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    G12C-mutated chemorefractory metastatic colorectal cancer (mCRC). One hundred sixty patients were randomly assigned 1:1:1 to receive sotorasib 960 mg-panitumumab (n = 53), sotorasib 240 mg-panitumumab (n = 53), or investigator's choice (n = 54; crossover permitted after primary analysis). Overall survival (OS) analysis, a key secondary end point, although not adequately powered, was prespecified at 50% maturity (after approximately 80 deaths). In this study, we report the OS, updated overall response rates (ORRs), and data for safety. After a median follow-up of 13.6 months, 24, 28, and 30 deaths occurred in the sotorasib 960 mg-panitumumab, sotorasib 240 mg-panitumumab, and investigator's choice arms, respectively; updated objective response rates (ORRs; 95% CI) were 30.2% (95% CI, 18.3 to 44.3), 7.5% (95% CI, 2.1 to 18.2), and 1.9% (95% CI, 0.0 to 9.9), respectively. Compared with investigator's choice, the hazard ratios (HRs [95% CI]) for OS were 0.70 (95% CI, 0.41 to 1.18; two-sided\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .20) with sotorasib 960 mg-panitumumab and 0.83 (95% CI, 0.49 to 1.39; two-sided\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .50) with sotorasib 240 mg-panitumumab. No new safety signals were observed. Although not statistically significant, the observed OS HR and ORR along with prior PFS and safety findings support sotorasib 960 mg-panitumumab as a standard of care in patients with chemorefractory\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    G12C mCRC.\n                  <\/jats:p>","DOI":"10.1200\/jco-24-02026","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T15:59:25Z","timestamp":1744387165000},"page":"2147-2154","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":55,"title":["Overall Survival Analysis of the Phase III CodeBreaK 300 Study of Sotorasib Plus Panitumumab Versus Investigator's Choice in Chemorefractory\n                    <i>KRAS<\/i>\n                    G12C Colorectal Cancer"],"prefix":"10.1200","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-8420","authenticated-orcid":true,"given":"Filippo","family":"Pietrantonio","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-0719","authenticated-orcid":true,"given":"Lisa","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-8453","authenticated-orcid":true,"given":"Taito","family":"Esaki","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Medical Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-0599","authenticated-orcid":true,"given":"Dominik Paul","family":"Modest","sequence":"additional","affiliation":[{"name":"Medicine Department of Hematology, Oncology and Tumor Immunology, Charit\u00e9 - Universitaetsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Paez","family":"Lopez-Bravo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-4753","authenticated-orcid":true,"given":"Julien","family":"Taieb","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, SIRIC CARPEM Comprehensive Cancer Center, Department of Gastroenterology and Digestive Oncology, Hopital Europ\u00e9en Georges Pompidou, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1369-8201","authenticated-orcid":true,"given":"Michalis V.","family":"Karamouzis","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, National and Kapodistrian University of Athens\u2014School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-123X","authenticated-orcid":true,"given":"Erika","family":"Ruiz-Garcia","sequence":"additional","affiliation":[{"name":"GI Oncology Department &amp; Translational Medicine Laboratory, INCAN - Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-1997","authenticated-orcid":true,"given":"Tae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Oncology Department, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-953X","authenticated-orcid":true,"given":"Yasutoshi","family":"Kuboki","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and GI Oncology Department, National Cancer Center Hospital East, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Meriggi","sequence":"additional","affiliation":[{"name":"Oncology Department, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-1069","authenticated-orcid":true,"given":"David","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Medicine Department, The Royal Marsden Hospital, London and Sutton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7306-174X","authenticated-orcid":true,"given":"Kun-Huei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Oncology, National Taiwan University Hospital, Taipei City, Taiwan"},{"name":"Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Chan","sequence":"additional","affiliation":[{"name":"Amgen Inc., Thousand Oaks, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-504X","authenticated-orcid":true,"given":"Joseph","family":"Chao","sequence":"additional","affiliation":[{"name":"Amgen Inc., Thousand Oaks, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-964X","authenticated-orcid":true,"given":"Qui","family":"Tran","sequence":"additional","affiliation":[{"name":"Amgen Inc., Thousand Oaks, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-4841","authenticated-orcid":true,"given":"Chiara","family":"Cremolini","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-5488","authenticated-orcid":true,"given":"Marwan","family":"Fakih","sequence":"additional","affiliation":[{"name":"Medical Oncology &amp; Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_11_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308795"},{"key":"e_1_3_11_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414325"},{"key":"e_1_3_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61900-X"},{"key":"e_1_3_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00772-9"},{"key":"e_1_3_11_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214963"},{"key":"e_1_3_11_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02240-8"},{"key":"e_1_3_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.102945"},{"key":"e_1_3_11_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0217"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO-24-02026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T17:59:18Z","timestamp":1750960758000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-24-02026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":8,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1200\/JCO-24-02026"],"URL":"https:\/\/doi.org\/10.1200\/jco-24-02026","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}