{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:56:39Z","timestamp":1774497399386,"version":"3.50.1"},"reference-count":8,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"18","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2025,6,20]]},"abstract":"<jats:p>\n            The MD Anderson dose-escalated, hypofractionated prostate radiation study was a phase III randomized trial comparing conventionally fractionated intensity-modulated radiation therapy (CIMRT, 75.6 Gy in 1.8-Gy fractions) with dose-escalated, hypofractionated intensity-modulated radiation (HIMRT, 72 Gy in 2.4-Gy fractions) in patients with localized prostate cancer, predominantly low-risk and intermediate-risk disease. The initial publication highlighted statistically fewer treatment failures in the HIMRT arm. We present long-term updated 13-year outcomes to determine whether cancer control benefit was maintained and to evaluate distant metastases post hoc. With a median follow-up of 13.2 years (IQR, 8.8-15.9 years), treatment failure occurred less frequently in men undergoing HIMRT (n = 13) compared with those undergoing CIMRT (n = 22), although the difference no longer meets statistical significance (\n            <jats:italic toggle=\"yes\">P =<\/jats:italic>\n            .08). Distant metastases were rare, and no statistically significant difference was noted (\n            <jats:italic toggle=\"yes\">P<\/jats:italic>\n            = .2). There remained no statistically significant difference in late GI 2+ (10-year 10% HIMRT\n            <jats:italic toggle=\"yes\">v<\/jats:italic>\n            4% CIMRT,\n            <jats:italic toggle=\"yes\">P<\/jats:italic>\n            = .09) or genitourinary grade 2+ toxicity (10-year 26%\n            <jats:italic toggle=\"yes\">v<\/jats:italic>\n            23%,\n            <jats:italic toggle=\"yes\">P<\/jats:italic>\n            = .5).\n          <\/jats:p>","DOI":"10.1200\/jco-24-02057","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T19:59:08Z","timestamp":1747252748000},"page":"2044-2048","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Hypofractionated, Dose-Escalated Radiation Versus Conventionally Fractionated Radiation for Localized Prostate Cancer: Long-Term Update of a Phase III, Prospective, Randomized Controlled Trial"],"prefix":"10.1200","volume":"43","clinical-trial-number":[{"clinical-trial-number":"nct00667888","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8107-2799","authenticated-orcid":true,"given":"Comron","family":"Hassanzadeh","sequence":"first","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Kuban","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Pasyar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-2042","authenticated-orcid":true,"given":"Roland","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Troncoso","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maheen","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Schlembach","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-575X","authenticated-orcid":true,"given":"Quynh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6517-7884","authenticated-orcid":true,"given":"Steven","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-657X","authenticated-orcid":true,"given":"Osama","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-2937","authenticated-orcid":true,"given":"Ryan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5915-1327","authenticated-orcid":true,"given":"Chad","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6644-9802","authenticated-orcid":true,"given":"Weiliang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Kudchadker","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungtaek","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.9868"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02445"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.6_suppl.304"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(03)00051-X"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.4189"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00567-7"},{"key":"e_1_3_9_8_2","volume-title":"Guidelines Detail","unstructured":"Guidelines Detail. https:\/\/www.nccn.org"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2018.08.002"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO-24-02057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T21:59:52Z","timestamp":1750111192000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-24-02057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":8,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,6,20]]}},"alternative-id":["10.1200\/JCO-24-02057"],"URL":"https:\/\/doi.org\/10.1200\/jco-24-02057","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"2024-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}