{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:47:19Z","timestamp":1792392439708,"version":"4.4.0"},"reference-count":191,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:p>\n            <jats:italic>ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the<\/jats:italic>\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.asco.org\/guideline-methodology\">\n              <jats:italic>ASCO Guidelines Methodology Manual<\/jats:italic>\n            <\/jats:ext-link>\n            <jats:italic>. ASCO Guidelines follow the<\/jats:italic>\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/society.asco.org\/about-asco\/legal\/conflict-interest-coi\">\n              <jats:italic>ASCO Conflict of Interest Policy for Clinical Practice Guidelines<\/jats:italic>\n            <\/jats:ext-link>\n            .\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>\n              Clinical Practice Guidelines and other guidance (\u201cGuidance\u201d) provided by ASCO is not a comprehensive or definitive guide to treatment options. It is intended for voluntary use by clinicians and should be used in conjunction with independent professional judgment. Guidance may not be applicable to all patients, interventions, diseases or stages of diseases. Guidance is based on review and analysis of relevant literature and is not intended as a statement of the standard of care. ASCO does not endorse third-party drugs, devices, services, or therapies and assumes no responsibility for any harm arising from or related to the use of this information. See complete disclaimer in\n              <jats:xref ref-type=\"app\">Appendix 1<\/jats:xref>\n              and\n              <jats:xref ref-type=\"app\">2<\/jats:xref>\n              (online only) for more\n            <\/jats:italic>\n            .\n          <\/jats:p>\n          <jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>To provide evidence-based recommendations to practicing physicians and others on the management of pleural mesothelioma (PM).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>ASCO convened an Expert Panel of medical oncology, thoracic surgery, radiation oncology, pathology, cancer genetics, and advocacy experts to conduct an updated literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2016 through 2024. Outcomes of interest included survival, disease-free or recurrence-free survival, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>The literature search identified 110 additional relevant studies to inform the evidence base for this guideline.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RECOMMENDATIONS<\/jats:title>\n            <jats:p>Evidence-based recommendations were developed for surgical cytoreduction, immunotherapy, chemotherapy, pathology, and germline testing in patients with PM.<\/jats:p>\n            <jats:p>\n              Additional information is available at\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.asco.org\/thoracic-cancer-guidelines\">www.asco.org\/thoracic-cancer-guidelines<\/jats:ext-link>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/jco-24-02425","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T20:59:26Z","timestamp":1736369966000},"page":"1006-1038","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":64,"title":["Treatment of Pleural Mesothelioma: ASCO Guideline Update"],"prefix":"10.1200","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-842X","authenticated-orcid":true,"given":"Hedy L.","family":"Kindler","sequence":"first","affiliation":[{"name":"University of Chicago Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1896","authenticated-orcid":true,"given":"Nofisat","family":"Ismaila","sequence":"additional","affiliation":[{"name":"American Society of Clinical Oncology, Alexandria, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8764-4359","authenticated-orcid":true,"given":"Lyudmila","family":"Bazhenova","sequence":"additional","affiliation":[{"name":"University of California San Diego Moores Cancer Center, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-3126","authenticated-orcid":true,"given":"Quincy","family":"Chu","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-5479","authenticated-orcid":true,"given":"Jane E.","family":"Churpek","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison and Carbone Cancer Center, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-9257","authenticated-orcid":true,"given":"Ibiayi","family":"Dagogo-Jack","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-8323","authenticated-orcid":true,"given":"Darren S.","family":"Bryan","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8171-4106","authenticated-orcid":true,"given":"Michael W.","family":"Drazer","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-6344","authenticated-orcid":true,"given":"Patrick","family":"Forde","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya N.","family":"Husain","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-2294","authenticated-orcid":true,"given":"Jennifer L.","family":"Sauter","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Rusch","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope A.","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4531-3396","authenticated-orcid":true,"given":"B.C. 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