{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:46:08Z","timestamp":1791942368290,"version":"4.3.4"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2025,10,10]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>\n              The phase III APOLLO trial prospectively compared the efficacy of arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) regimen (ATRA and ATO [ATRA-ATO]) plus low-dose idarubicin versus standard ATRA plus anthracycline-based chemotherapy (ATRA-CHT) regimen (ie, ATRA and idarubicin regimen) in patients with high-risk acute promyelocytic leukemia (APL; EudraCT 2015-01151-68; ClinicalTrials.gov identifier:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02688140\">NCT02688140<\/jats:ext-link>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>\n              Adult patients with newly diagnosed high-risk APL in the ATRA-ATO arm received ATO 0.15 mg\/kg once daily and ATRA 45 mg\/m\n              <jats:sup>2<\/jats:sup>\n              twice daily until complete remission (CR), with two doses of idarubicin 12 mg\/m\n              <jats:sup>2<\/jats:sup>\n              on days 1 and 3, followed by consolidation therapy (four ATRA-ATO cycles). Patients in the ATRA-CHT arm received induction with ATRA 45 mg\/m\n              <jats:sup>2<\/jats:sup>\n              twice daily and idarubicin 12 mg\/m\n              <jats:sup>2<\/jats:sup>\n              once daily on days 1, 3, 5, and 7, followed by three cycles of chemotherapy-based consolidation and 2 years of maintenance therapy. The primary study end point was event-free survival (EFS) at 2 years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              As of July 2022, 133 eligible patients had received either ATRA-ATO (n = 68) or ATRA-CHT (n = 65). The study was discontinued prematurely because of slow accrual during the COVID-19 pandemic. After a median follow-up of 37 months (range, 1.7-88.6 months), 2-year EFS was 88% in the ATRA-ATO arm and 71% in the ATRA-CHT arm (HR, 0.4 [95% CI, 0.17 to 0.92]; log-rank test\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .02). At a median of 7.8 and 12.1 months from achievement of CR, molecular relapse occurred in one (1.5%) ATRA-ATO patient versus eight (12.3%) ATRA-CHT patients (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .014). Overall, 32% and 68% of patients receiving ATRA-ATO and ATRA-CHT, respectively, reported serious treatment-emergent adverse events (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt; .01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>The results of the APOLLO trial support the use of ATO and ATRA for the treatment of newly diagnosed patients with high-risk APL.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/jco-25-00535","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T19:59:48Z","timestamp":1755547188000},"page":"3160-3169","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":25,"title":["Arsenic Trioxide and All-Trans Retinoic Acid Combination Therapy for the Treatment of High-Risk Acute Promyelocytic Leukemia: Results From the APOLLO Trial"],"prefix":"10.1200","volume":"43","clinical-trial-number":[{"clinical-trial-number":"nct02688140","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-3239","authenticated-orcid":true,"given":"Uwe","family":"Platzbecker","sequence":"first","affiliation":[{"name":"University Hospital Carl Gustav Carus and TU Dresden - Faculty of Medicine, Medical Clinic 1, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Ad\u00e8s","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie S\u00e9niors, Assistance Publique h\u00f4pitaux de Paris, Paris Saint-Louis Leukemia Institute France, H\u00f4pital Saint Louis, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3275-5593","authenticated-orcid":true,"given":"Pau","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-4901","authenticated-orcid":true,"given":"Emanuele","family":"Ammatuna","sequence":"additional","affiliation":[{"name":"Afd. 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