{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:52:43Z","timestamp":1790056363514,"version":"4.0.1"},"reference-count":63,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"20","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2025,7,10]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Family and friend caregivers of patients undergoing hematopoietic stem-cell transplantation (HSCT) struggle with immense caregiving burden, leading to substantial quality of life (QOL) impairments and psychological distress. Yet, interventions to address caregivers' needs are limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>We conducted a randomized controlled trial of a psychosocial digital application (BMT-CARE App) versus usual care for adult caregivers of patients with hematologic malignancies undergoing HSCT. The BMT-CARE App included five modules combining psychoeducation and evidence-based behavior change strategies. Participants completed self-report measures at baseline and day 60 post-HSCT. The primary end point was QOL at day 60 assessed by the CareGiver Oncology QOL (CarGOQOL) measure. We also assessed caregiving burden (Caregiver Reaction Assessment), anxiety and depression symptoms (Hospital Anxiety and Depression Scale), and post-traumatic stress disorder (PTSD) symptoms (PTSD Checklist [PCL-5]). We used analysis of covariance adjusting for baseline scores to assess the effect of the intervention on study outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Between February 2023 and July 2024, we enrolled 125 of 174 approached caregivers (71.8%). Participants assigned to the BMT-CARE App used the app for a median of 146.9 minutes (range, 0-384.8). At day 60, BMT-CARE App caregivers reported clinically and significantly better QOL than those assigned to usual care (adjusted means = 76.3\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              69.9,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .006). BMT-CARE App participants also reported significantly lower caregiving burden (11.2\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              12.3,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .023), depression (3.8\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              5.6,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .002), and PTSD symptoms (26.1\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              31.3,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .012). The groups did not differ significantly in anxiety symptoms at day 60.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>The BMT-CARE App led to significantly improved QOL, caregiving burden, depression, and PTSD symptoms among HSCT caregivers. This intervention should be tested in a multicenter study with a diverse HSCT caregiver population to determine generalizability and scalability.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/jco-25-00713","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T12:50:53Z","timestamp":1748609453000},"page":"2265-2275","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":8,"title":["BMT-CARE App: A Randomized Controlled Trial of a Psychosocial Digital Application for Caregivers of Patients Undergoing Hematopoietic Stem-Cell Transplantation"],"prefix":"10.1200","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-624X","authenticated-orcid":true,"given":"Jamie M.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, 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