{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:38:25Z","timestamp":1789025905965,"version":"build-2803163510"},"reference-count":12,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"21","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,7,20]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>\n                      The WSG TP-II trial (ClinicalTrials.gov identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03272477\">NCT03272477<\/jats:ext-link>\n                      ) was designed to compare the impact of 12 weeks of neoadjuvant trastuzumab + pertuzumab combined with endocrine therapy (ET) versus chemotherapy (once per week paclitaxel) on the pathologic complete response (pCR) rate and survival in hormone receptor\u2013positive\/human epidermal growth factor receptor 2 (HER2)\u2013positive early breast cancer (eBC). Analysis of the primary end point revealed that the pCR rate in the paclitaxel + trastuzumab + pertuzumab arm was superior compared with that in the ET + trastuzumab + pertuzumab arm (56.4%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      23.7%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Here, we present the final 5-year survival analysis of this multicenter, randomized phase II, open-label trial, with 207 participants randomly assigned 1:1 to the two study arms. All patients received dual HER2 blockade in the adjuvant setting. Further standard chemotherapy was obligatory in all patients with non-pCR, but optional after pCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>After a 5-year follow-up, an overall survival rate of 100% (95% CI, 100.0 to 100.0) in the ET arm versus 97.9% (95% CI, 95.0 to 100.0) in the paclitaxel arm was estimated. The corresponding 5-year event-free survival-ductal carcinoma in situ rates were 92.1% (95% CI, 86.6 to 97.9) versus 94.8% (95% CI, 90.5 to 99.3), and 5-year invasive disease-free survival rates were 97.7% (95% CI, 94.5 to 100.0) versus 79.8% (95% CI, 55.6 to 100.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our results show excellent survival outcomes in patients with hormone receptor\u2013positive\/HER2\u2013positive eBC who received either a de-escalated chemotherapy or ET in combination with trastuzumab and pertuzumab in the neoadjuvant setting. WSG TP-II confirms the safety and efficacy of a de-escalated and well-tolerated neoadjuvant therapy approach with pCR-guided adjuvant therapy in hormone receptor\u2013positive\/HER2\u2013positive eBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-25-01047","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T19:59:08Z","timestamp":1779134348000},"page":"1974-1980","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Survival Analysis of the WSG TP-II Trial: Neoadjuvant Trastuzumab and Pertuzumab Plus Endocrine Therapy Versus Chemotherapy in Hormone Receptor\u2013Positive\/Human Epidermal Growth Factor Receptor 2\u2013Positive Early Breast Cancer"],"prefix":"10.1200","volume":"44","clinical-trial-number":[{"clinical-trial-number":"nct03272477","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-7544","authenticated-orcid":true,"given":"Oleg","family":"Gluz","sequence":"first","affiliation":[{"name":"Breast Center, Evangelisches Krankenhaus Bethesda Klinik, Moenchengladbach, Germany"},{"name":"West German Study Group, Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0143-0507","authenticated-orcid":true,"given":"Ulrike A.","family":"Nitz","sequence":"additional","affiliation":[{"name":"West German Study Group, Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-7839","authenticated-orcid":true,"given":"Matthias","family":"Christgen","sequence":"additional","affiliation":[{"name":"Pathology, MHH\u2014Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-494X","authenticated-orcid":true,"given":"Sherko","family":"Kuemmel","sequence":"additional","affiliation":[{"name":"Breast Unit, Kliniken Essen Mitte Evangelische Huyssens-Stiftung, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2723-1154","authenticated-orcid":true,"given":"Johannes","family":"Holtschmidt","sequence":"additional","affiliation":[{"name":"Breast Center, St Elisabeth Clinics Hohenlind, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Palleos Healthcare GmbH, Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6715-6337","authenticated-orcid":true,"given":"Philip","family":"Raeth","sequence":"additional","affiliation":[{"name":"Palleos Healthcare GmbH, Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1227-1118","authenticated-orcid":true,"given":"Andreas D.","family":"Hartkopf","sequence":"additional","affiliation":[{"name":"Center for Women's Health, University Hospital of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-6871","authenticated-orcid":true,"given":"Kerstin","family":"Luedtke-Heckenkamp","sequence":"additional","affiliation":[{"name":"Oncology Department, Franziskus-Hospital Harderberg\u2014Niels-Stensen-Kliniken GmbH, Georgsmarienhuette, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6366-9340","authenticated-orcid":true,"given":"Marianne","family":"Just","sequence":"additional","affiliation":[{"name":"Oncology, Onkologische Schwerpunktpraxis, Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"von Schumann","sequence":"additional","affiliation":[{"name":"Breast Center Niederrhein, Johanniter Bethesda Moenchengladbach, Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Polata","sequence":"additional","affiliation":[{"name":"Oncology, Oncological Center Spandau, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2008-6775","authenticated-orcid":true,"given":"Timo","family":"Schinkoethe","sequence":"additional","affiliation":[{"name":"Breast Center, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Munich, Ludwig Maximilians University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-717X","authenticated-orcid":true,"given":"Monika K.","family":"Graeser","sequence":"additional","affiliation":[{"name":"West German Study Group, Moenchengladbach, Germany"},{"name":"Department of Obstetrics and Gynecology, University Witten-Herdecke, Witten, Germany"},{"name":"Bethesda Hospital, Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Kates","sequence":"additional","affiliation":[{"name":"West German Study Group, Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Wuerstlein","sequence":"additional","affiliation":[{"name":"Breast Center, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Munich, Ludwig Maximilians University Hospital, Munich, 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