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Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the<\/jats:italic>\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/asco.org\/guideline-methodology\">\n              <jats:italic toggle=\"yes\">ASCO Guidelines Methodology Manual<\/jats:italic>\n            <\/jats:ext-link>\n            <jats:italic toggle=\"yes\">. ASCO Living Guidelines follow the<\/jats:italic>\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/asco.org\/rwc\">\n              <jats:italic toggle=\"yes\">ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines<\/jats:italic>\n            <\/jats:ext-link>\n            <jats:italic toggle=\"yes\">\n              . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information (\n              <jats:xref ref-type=\"app\">Appendix 1<\/jats:xref>\n              and\n              <jats:xref ref-type=\"app\">Appendix 2<\/jats:xref>\n              ). Updates are published regularly and can be found at\n            <\/jats:italic>\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ascopubs.org\/nsclc-non-da-living-guideline\">\n              <jats:italic toggle=\"yes\">https:\/\/ascopubs.org\/nsclc-non-da-living-guideline<\/jats:italic>\n            <\/jats:ext-link>\n            .\n          <\/jats:p>","DOI":"10.1200\/jco-25-01062","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T19:59:16Z","timestamp":1752782356000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":21,"title":["Therapy for Stage IV Non\u2013Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2025.1"],"prefix":"10.1200","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-4886","authenticated-orcid":true,"given":"Dwight H.","family":"Owen","sequence":"first","affiliation":[{"name":"Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-8360","authenticated-orcid":true,"given":"Balazs","family":"Halmos","sequence":"additional","affiliation":[{"name":"Montefiore Einstein Comprehensive Center for Cancer Care, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-5051","authenticated-orcid":true,"given":"Sonam","family":"Puri","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-3087","authenticated-orcid":true,"given":"Angel","family":"Qin","sequence":"additional","affiliation":[{"name":"University of Michigan Health System, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1896","authenticated-orcid":true,"given":"Nofisat","family":"Ismaila","sequence":"additional","affiliation":[{"name":"American Society of Clinical Oncology (ASCO), Alexandria, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7458-9802","authenticated-orcid":true,"given":"Fawzi","family":"Abu Rous","sequence":"additional","affiliation":[{"name":"Henry Ford Cancer Institute\/Henry Ford Health System, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3157-9521","authenticated-orcid":true,"given":"Krishna","family":"Alluri","sequence":"additional","affiliation":[{"name":"Texas Oncology, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-7912","authenticated-orcid":true,"given":"Janet","family":"Freeman-Daily","sequence":"additional","affiliation":[{"name":"The ROS1ders, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narinder","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Yolanda G. 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