{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:35:33Z","timestamp":1790962533637,"version":"4.1.0"},"reference-count":14,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,2,10]]},"abstract":"<jats:p>\n                    We report 5-year results of the phase III randomized TRIPLETE study. Eligible patients with\n                    <jats:italic toggle=\"yes\">RAS\/BRAF<\/jats:italic>\n                    wild-type metastatic colorectal cancer (mCRC) received first-line modified fluorouracil, leucovorin, oxaliplatin (mFOLFOX)\/panitumumab (control group, n = 217) versus modified fluorouracil, leucovorin, oxaliplatin, irinotecan (mFOLFOXIRI)\/panitumumab (experimental group, n = 218). We present overall survival (OS) and updated outcomes in the intention-to-treat population. The median follow-up was 60.2 months (IQR, 49.3-70.0). The median OS was 41.1 and 33.3 months for experimental and control groups, respectively (hazard ratio [HR], 0.79 [95% CI, 0.63 to 0.99];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .049). OS outcomes favored the experimental group regardless of clinical features. No differences in objective response rate (primary end point; 75%\/78%, odds ratio, 0.84 [95% CI, 0.54 to 1.31];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .442), early tumor shrinkage rate (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .954), depth of response (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .573), no residual tumor resection rate (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .329), and progression-free survival (HR, 0.95 [95% CI, 0.78 to 1.16];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .606) were confirmed. Among patients alive at the time of disease progression, the median postprogression survival was 24.6 and 17.7 months for experimental and control groups, respectively (HR, 0.79 [95% CI, 0.62 to 1.01];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .062). Similar proportions of patients in both groups received subsequent lines of therapy (control\/experimental: second line 73%\/71%, third line 51%\/49%, fourth line 31%\/32%), as well as nonpalliative locoregional treatments (control\/experimental: 16%\/16%). Upfront mFOLFOXIRI\/panitumumab significantly improves OS compared with mFOLFOX\/panitumumab in patients with\n                    <jats:italic toggle=\"yes\">RAS\/BRAF<\/jats:italic>\n                    wild-type mCRC.\n                  <\/jats:p>","DOI":"10.1200\/jco-25-01337","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:00:05Z","timestamp":1767906005000},"page":"361-369","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":15,"title":["Upfront Modified FOLFOXIRI Plus Panitumumab for\n                    <i>RAS\/BRAF<\/i>\n                    Wild-Type Metastatic Colorectal Cancer: Final Results of the Phase III TRIPLETE Study"],"prefix":"10.1200","volume":"44","clinical-trial-number":[{"clinical-trial-number":"nct03231722","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7713-4005","authenticated-orcid":true,"given":"Veronica","family":"Conca","sequence":"first","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"},{"name":"Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3777-8471","authenticated-orcid":true,"given":"Daniele","family":"Rossini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-3188","authenticated-orcid":true,"given":"Carlotta","family":"Antoniotti","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"},{"name":"Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-8138","authenticated-orcid":true,"given":"Sara","family":"Lonardi","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit 1, Veneto Institute of Oncology IOV\u2014IRCCS, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-8420","authenticated-orcid":true,"given":"Filippo","family":"Pietrantonio","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Moretto","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Antonuzzo","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"},{"name":"Clinical Oncology Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Randon","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Lavacchi","sequence":"additional","affiliation":[{"name":"Clinical Oncology Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-9098","authenticated-orcid":true,"given":"Carmelo","family":"Pozzo","sequence":"additional","affiliation":[{"name":"Medical Oncology, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-3434","authenticated-orcid":true,"given":"Federica","family":"Marmorino","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"},{"name":"Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-4653","authenticated-orcid":true,"given":"Francesca","family":"Bergamo","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit 1, Veneto Institute of Oncology IOV\u2014IRCCS, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Tamburini","sequence":"additional","affiliation":[{"name":"Oncology and Palliative Care Department, Tricase City Hospital, Tricase, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-240X","authenticated-orcid":true,"given":"Alessandro","family":"Passardi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori,\u201d Meldola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6690-2101","authenticated-orcid":true,"given":"Roberta","family":"Fazio","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-9872","authenticated-orcid":true,"given":"Sabina","family":"Murgioni","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit 1, Veneto Institute of Oncology IOV\u2014IRCCS, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-408X","authenticated-orcid":true,"given":"Beatrice","family":"Borelli","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Buonadonna","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Maria","family":"Germani","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"},{"name":"Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5380-3144","authenticated-orcid":true,"given":"Vincenzo","family":"Formica","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-2517","authenticated-orcid":true,"given":"Martina","family":"Carullo","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"},{"name":"Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5005-0880","authenticated-orcid":true,"given":"Roberto","family":"Bordonaro","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Azienda Ospedaliera di Rilievo Nazionale e Alta Specializzazione (ARNAS), Ospedale Garibaldi, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Aprile","sequence":"additional","affiliation":[{"name":"Department of Oncology, San Bortolo General Hospital, Azienda ULSS8 Berica, Vicenza, Italy"},{"name":"Department of Oncology, Academic Hospital of Udine ASUFC, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zaniboni","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Poliambulanza Foundation, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-8989","authenticated-orcid":true,"given":"Gianluca","family":"Masi","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"},{"name":"Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-4047","authenticated-orcid":true,"given":"Luca","family":"Boni","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San 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