{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:23:31Z","timestamp":1785713011863,"version":"3.56.0"},"reference-count":27,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Hot flashes are a common side effect reported by men receiving androgen-deprivation therapy (ADT) for the treatment of prostate cancer. We sought to determine whether oxybutynin could improve hot flash symptoms in men with prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>Patients with prostate cancer receiving a stable regimen of ADT with at least 28 hot flashes per week were randomly assigned to receive either oxybutynin 2.5 mg twice daily, oxybutynin 5 mg twice daily, or matching placebo for 6 weeks. The primary end point was the change in patient-reported hot flash scores since baseline at 6 weeks. Additional outcomes included incidence of adverse events (AEs), changes since baseline in Hot Flash\u2013Related Daily Interference Scale (HFRDIS) scores, and patient-reported symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Eighty-eight patients were enrolled, with the 81 participants eligible for final analysis reporting an average of 10.1 (standard deviation [SD], 5.55) hot flashes per day and an average daily hot flash score of 18.2 (SD, 13.5) included in final analysis. On average, patients on the placebo arm, 2.5 mg oxybutynin arm, and 5 mg oxybutynin arm had reductions in hot flashes\/day of 2.15, 4.77 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02), and 6.89 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), respectively. Daily hot flash scores for placebo, 2.5 mg oxybutynin, and 5 mg oxybutynin reduced by an average of 4.85, 9.94 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .07), and 13.95 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002) points, respectively. No treatment-related grade 3+ AEs occurred. HFRDIS total scores improved by 14.2 and 20.7 points in the 2.5 mg (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .042) and 5 mg (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01) oxybutynin arms, respectively, compared with a 3.1-point improvement with placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Oxybutynin is superior to a placebo for the management of ADT-associated hot flashes in men with prostate cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-25-01486","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T20:59:09Z","timestamp":1769461149000},"page":"1198-1205","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Alliance A222001: Oxybutynin Versus Placebo for the Treatment of Hot Flashes in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer"],"prefix":"10.1200","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-0607","authenticated-orcid":true,"given":"Bradley J.","family":"Stish","sequence":"first","affiliation":[{"name":"Mayo Clinic Department of Radiation Oncology, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-6193","authenticated-orcid":true,"given":"Gina L.","family":"Mazza","sequence":"additional","affiliation":[{"name":"Alliance Statistics and Data Management Center, Mayo Clinic, Scottsdale, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2302-4171","authenticated-orcid":true,"given":"Jones T.","family":"Nauseef","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; 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