{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:56:08Z","timestamp":1793534168709,"version":"4.5.0"},"reference-count":15,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>\n                      NRG Oncology\/Alliance LU005 (ClinicalTrials.gov identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03811002\">NCT03811002<\/jats:ext-link>\n                      ) tested the addition of atezolizumab to concurrent chemoradiation (CRT) in this open-label, phase III international trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Patients with limited-stage small cell lung cancer (LS-SCLC), stage Tx-IV, N0-3, and M0 with Eastern Cooperative Group performance status (PS) 0-2 received one cycle of chemotherapy (platinum\/etoposide) before study registration and were randomly assigned to CRT alone versus CRT plus concurrent and adjuvant atezolizumab, 1,200 mg once daily, every 3 weeks until investigator-assessed progression or intolerable side effects for a maximum of 17 cycles. Patients were stratified by choice of chemotherapy (cisplatin\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      carboplatin), radiation fractionation schedule (66 Gy once daily\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      45 Gy twice daily), sex, and PS (0\/1\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      2). The primary end point was overall survival (OS). Secondary end points included investigator-assessed progression-free survival (PFS), objective response rate, local control, and distant-metastasis-free survival (DMFS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>patients were randomly assigned from May 2019 to December 2023. The median OS was 36.1 months (95% CI, 28.1 to 42.5) for the CRT-alone arm and 31.1 months (95% CI, 28.5 to 44.7) for the CRT + atezolizumab arm, respectively (hazard ratio [HR], 1.03 [95% CI, 0.80 to 1.32]). The median PFS was 11.4 months (95% CI, 10.3 to 13.2) for the CRT-alone arm and 12.1 months (95% CI, 10.9 to 15.2) for the CRT + atezolizumab arm, respectively (HR, 0.98 [95% CI, 0.79 to 1.22]). The median DMFS was 13.0 months (95% CI, 11.3 to 18.2) for the CRT-alone arm and 16.8 months (95% CI, 12.1 to 21.6) for the CRT + atezolizumab arm (HR, 0.96 [95% CI, 0.76 to 1.21]). No unexpected safety signals with concurrent atezolizumab were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Concurrent and adjuvant atezolizumab with chemoradiation did not improve survival in patients with LS-SCLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-25-01569","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T20:59:40Z","timestamp":1768337980000},"page":"630-640","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":31,"title":["Chemoradiation \u00b1 Atezolizumab in Limited-Stage Small Cell Lung Cancer: Results of NRG Oncology\/Alliance LU005"],"prefix":"10.1200","volume":"44","clinical-trial-number":[{"clinical-trial-number":"nct03811002","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-9878","authenticated-orcid":true,"given":"Kristin A.","family":"Higgins","sequence":"first","affiliation":[{"name":"City of Hope, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-1981","authenticated-orcid":true,"given":"Chen","family":"Hu","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, Philadelphia, PA"},{"name":"Johns Hopkins University, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-3066","authenticated-orcid":true,"given":"Helen J.","family":"Ross","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-5371","authenticated-orcid":true,"given":"Salma K.","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute, New Brunswick, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-396X","authenticated-orcid":true,"given":"David E.","family":"Kozono","sequence":"additional","affiliation":[{"name":"Dana-Farber\/Harvard Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-7728","authenticated-orcid":true,"given":"Taofeek K.","family":"Owonikoko","sequence":"additional","affiliation":[{"name":"University of Maryland\/Greenebaum Cancer Center, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Radiation Oncology, Richmond, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-0845","authenticated-orcid":true,"given":"Terence M.","family":"Williams","sequence":"additional","affiliation":[{"name":"City of Hope National Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-8502","authenticated-orcid":true,"given":"James","family":"Welsh","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffry P.","family":"Simko","sequence":"additional","affiliation":[{"name":"UCSF Medical Center, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2703-9776","authenticated-orcid":true,"given":"B","family":"Movsas","sequence":"additional","affiliation":[{"name":"Henry Ford Cancer Institute, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-5325","authenticated-orcid":true,"given":"Canhua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Emory University Hospital\/Winship Cancer Institute, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5548-7686","authenticated-orcid":true,"given":"Kyoichi","family":"Kaira","sequence":"additional","affiliation":[{"name":"Saitama Medical University International Medical Center, Yamane, Hidaka City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Heartland NCORP: Springfield Clinic, Department of Hematology and Oncology, Springfield, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-7496","authenticated-orcid":true,"given":"Pranshu","family":"Mohindra","sequence":"additional","affiliation":[{"name":"University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-5165","authenticated-orcid":true,"given":"Elie G.","family":"Dib","sequence":"additional","affiliation":[{"name":"Trinity Health Cancer Center, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-4895","authenticated-orcid":true,"given":"Jeremy","family":"Brownstein","sequence":"additional","affiliation":[{"name":"Ohio State University Comprehensive Cancer Center, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4324-8044","authenticated-orcid":true,"given":"Stephen","family":"Chun","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Kuzma","sequence":"additional","affiliation":[{"name":"First Health of the Carolinas\/SCOR NCORP, Pinehurst, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-0402","authenticated-orcid":true,"given":"Rupesh","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Miami Cancer Institute, Baptist Health South Florida, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-0606","authenticated-orcid":true,"given":"Adedayo A.","family":"Onitilo","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Health System, Weston, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8276-1772","authenticated-orcid":true,"given":"Yuhchyau","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Rochester, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-8011","authenticated-orcid":true,"given":"Thomas E.","family":"Stinchcombe","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-1194","authenticated-orcid":true,"given":"Rebecca","family":"Paulus","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, Philadelphia, PA"},{"name":"American College of Radiology, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9305-7396","authenticated-orcid":true,"given":"Jeffrey D.","family":"Bradley","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_12_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916623"},{"key":"e_1_3_12_3_2","first-page":"889","article-title":"Atezolizumab plus chemotherapy in small-cell lung cancer. Reply","volume":"380","author":"Horn L","year":"2019","unstructured":"Horn L, Liu SV: Atezolizumab plus chemotherapy in small-cell lung cancer. Reply. N Engl J Med 380:889-890, 2019","journal-title":"N Engl J Med"},{"key":"e_1_3_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30539-8"},{"key":"e_1_3_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30318-2"},{"key":"e_1_3_12_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01359"},{"key":"e_1_3_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.10.020"},{"key":"e_1_3_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(74)90015-0"},{"key":"e_1_3_12_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1740774510369019"},{"key":"e_1_3_12_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901283400403"},{"key":"e_1_3_12_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2404873"},{"key":"e_1_3_12_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1298"},{"key":"e_1_3_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2020.02.009"},{"key":"e_1_3_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2023.02.001"},{"key":"e_1_3_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30230-9"},{"key":"e_1_3_12_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00221"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO-25-01569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:59:36Z","timestamp":1772751576000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-25-01569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,3,10]]}},"alternative-id":["10.1200\/JCO-25-01569"],"URL":"https:\/\/doi.org\/10.1200\/jco-25-01569","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"assertion":[{"value":"2025-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}