{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:18:26Z","timestamp":1790878706822,"version":"4.1.0"},"reference-count":36,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"\n PURPOSE<\/jats:title>\n \n BRCA<\/jats:italic>\n carriers face high risks of developing both breast and ovarian\/fallopian tube cancers (hereafter referred to as\n ovarian<\/jats:italic>\n ). Among\n BRCA<\/jats:italic>\n carriers with ovarian cancer, it is not clear whether the risk of breast cancer is sufficiently high that risk-reducing mastectomy should be offered. This study aimed to assess the risk of breast cancer\n BRCA<\/jats:italic>\n carriers after a diagnosis of ovarian cancer.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n We included women with a pathogenic\/likely pathogenic variant in\n BRCA1<\/jats:italic>\n or\n BRCA2<\/jats:italic>\n , a diagnosis of ovarian cancer, and no other cancer history and no risk-reducing bilateral mastectomy. Women were followed for incident breast cancer from the date of ovarian cancer diagnosis or the date of baseline questionnaire, whichever came last. The 5-, 10-, and 15-year cumulative risks of breast cancer were compared for women with ovarian cancer and an age-matched set of control women without ovarian cancer.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n A total of 960 participants with ovarian cancer were identified (814\n BRCA1<\/jats:italic>\n and 146\n BRCA2<\/jats:italic>\n carriers). After a mean follow-up of 4.9 years, 41 women (4.3%) developed breast cancer, at a mean age at diagnosis of 57.5 years (range, 39-74). Actuarial cumulative breast cancer risks after ovarian cancer were 4.4%, 8.9%, and 11.5% at 5, 10, and 15 years, respectively. Only three breast cancer\u2013related deaths occurred. Among 741 age-matched\n BRCA<\/jats:italic>\n carriers\n without<\/jats:italic>\n ovarian cancer, actuarial cumulative risks of breast cancer were 20.9%, 38.6%, and 47.2% at 5, 10, and 15 years, respectively. The hazard ratio for breast cancer, after an ovarian cancer diagnosis, compared with no ovarian cancer, was 0.18 ([95% CI, 0.12 to 0.27];\n P<\/jats:italic>\n < .0001).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n After ovarian cancer,\n BRCA<\/jats:italic>\n carriers have a relatively low risk of breast cancer. Risk-reducing mastectomy should not be recommended routinely, but might be considered for long-term survivors. Magnetic resonance imaging surveillance and\/or mammography is a realistic alternative.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/jco-25-01648","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:59:06Z","timestamp":1772312346000},"page":"883-892","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic\/Likely Pathogenic Variant in\n BRCA1<\/i>\n or\n BRCA2<\/i>"],"prefix":"10.1200","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4614-9261","authenticated-orcid":true,"given":"Adriana I.","family":"Apostol","sequence":"first","affiliation":[{"name":"Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy"},{"name":"Women's College Research Institute, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Gronwald","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-3057","authenticated-orcid":false,"given":"Cezary","family":"Cybulski","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-8674","authenticated-orcid":true,"given":"Raymond H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, 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