{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:12Z","timestamp":1792818912755,"version":"4.5.0"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of adjuvant hepatic arterial infusion (HAI) of oxaliplatin combined with intravenous (IV) fluorouracil\/leucovorin (LV5FU2) after curative-intent surgery of \u22654 colorectal liver metastases (CRLM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients with an Eastern Cooperative Oncology Group performance status 0-1, who underwent resection or ablation of \u22654 CRLM after preoperative IV chemotherapy were enrolled. Patients were randomly assigned (1:1) to receive adjuvant oxaliplatin via HAI (HAI group, n = 50) or IV infusion (IV group, n = 49), both combined with IV LV5FU2 for at least 3 months. The primary end point was hepatic recurrence-free survival (h-RFS). Secondary end points included RFS, overall survival (OS), safety, and feasibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      After a median follow-up of 59 months (IQR, 45-71), the median h-RFS was 25 (95% CI, 16 to 37) months in the HAI group versus 12 (95% CI, 8 to 19) months in the IV group (hazard ratio [HR], 0.63 [95% CI, 0.40 to 0.99];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .047). Median RFS was 14 months (95% CI, 10 to 20) in the HAI group versus 9 months (95% CI, 7 to 11) in the IV group (HR, 0.63 [95% CI, 0.41 to 0.97];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03). Median OS was 74 months (95% CI, 51 to not defined) in the HAI group versus 57 months (95% CI, 37 to 69) in the IV group (HR, 0.61 [95% CI, 0.33 to 1.12];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .11). Five-year OS was 62% in the HAI arm compared with 47% in the IV arm. Grade 3 to 4 adverse events occurred in 58% of HAI patients and 32% of IV patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). No treatment-related deaths were reported. Four or more cycles of adjuvant chemotherapy were delivered in 81% of patients in the HAI group and 78% in the IV group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .75).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Adjuvant oxaliplatin HAI plus LV5FU2 improves h-RFS after curative-intent surgery of CRLM in high-risk patients, with an acceptable safety profile. These results support further evaluation in a phase III trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-25-01737","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:59:06Z","timestamp":1776887946000},"page":"1416-1429","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Postoperative Hepatic Arterial Infusion With Oxaliplatin After Surgery of Four or More Colorectal Liver Metastases: A Randomized Phase II Trial"],"prefix":"10.1200","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-4021","authenticated-orcid":true,"given":"Maximiliano","family":"Gelli","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Surgery and Interventional Radiology, Gustave Roussy Hospital, University of Paris-Saclay, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Ewald","sequence":"additional","affiliation":[{"name":"Department of Surgery, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-6803","authenticated-orcid":true,"given":"Marie-Laure","family":"Tanguy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Gustave Roussy, Universit\u00e9 Paris Saclay, Villejuif, France"},{"name":"Oncostat U1018, Inserm, University Paris-Saclay, Labeled Ligue Contre le Cancer, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Passot","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Hospital Lyon Sud, Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Quenet","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Institut R\u00e9gional du Cancer de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-3182","authenticated-orcid":false,"given":"Yann","family":"Touchefeu","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology, Institut des Maladies de l\u2019Appareil Digestif, University Hospital Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Senellart","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Institut de Canc\u00e9rologie de l\u2019Ouest, Centre Ren\u00e9 Gauducheau, Saint-Herblain, 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