{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:24:51Z","timestamp":1789457091240,"version":"build-2803163510"},"reference-count":11,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,2,20]]},"abstract":"<jats:p>\n                    <jats:boxed-text orientation=\"portrait\" position=\"float\" specific-use=\"update-notice\">\n                      <jats:p>\n                        <jats:bold>This guideline has been updated.<\/jats:bold>\n                      <\/jats:p>\n                      <jats:p>\n                        This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\" https:\/\/ascopubs.org\/guidelines\/systemic-therapy-patients-metastatic-castration-resistant-prostate-cancer\">online dynamic version<\/jats:ext-link>\n                        for the latest updates.\n                      <\/jats:p>\n                    <\/jats:boxed-text>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic toggle=\"yes\">Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the<\/jats:italic>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.asco.org\/guideline-methodology\">\n                      <jats:italic toggle=\"yes\">ASCO Guidelines Methodology Manual<\/jats:italic>\n                    <\/jats:ext-link>\n                    <jats:italic toggle=\"yes\">. ASCO Living Guidelines follow the<\/jats:italic>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.asco.org\/rwc\">\n                      <jats:italic toggle=\"yes\">ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines<\/jats:italic>\n                    <\/jats:ext-link>\n                    <jats:italic toggle=\"yes\">\n                      . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information (\n                      <jats:xref ref-type=\"app\">Appendix 1<\/jats:xref>\n                      and\n                      <jats:xref ref-type=\"app\">Appendix 2<\/jats:xref>\n                      ). Updates are published regularly and can be found at\n                    <\/jats:italic>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.asco.org\/genitourinary-cancer-guidelines\">\n                      <jats:italic toggle=\"yes\">www.asco.org\/genitourinary-cancer-guidelines<\/jats:italic>\n                    <\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1200\/jco-25-02693","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T20:59:53Z","timestamp":1768942793000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":10,"title":["Systemic Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer: ASCO Living Guideline, Version 2026.1"],"prefix":"10.1200","volume":"44","author":[{"given":"Mary-Ellen","family":"Taplin","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-0311","authenticated-orcid":false,"given":"Irbaz Bin","family":"Riaz","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-2925","authenticated-orcid":false,"given":"R. Bryan","family":"Rumble","sequence":"additional","affiliation":[{"name":"American Society of Clinical Oncology, Alexandria, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Arsalan Ahmed","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-5823","authenticated-orcid":false,"given":"Thomas A.","family":"Hope","sequence":"additional","affiliation":[{"name":"University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9096-3219","authenticated-orcid":false,"given":"Mariane Fontes","family":"Dias","sequence":"additional","affiliation":[{"name":"Oncoclinicas&amp;Co\u2014Medica Scientia Innovation Research (MEDSIR), Latin America Cooperative Group (LACOG)-Genito-Urinary, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"He","sequence":"additional","affiliation":[{"name":"Yale University, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9286-1972","authenticated-orcid":false,"given":"Sebastien J.","family":"Hotte","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-8703","authenticated-orcid":false,"given":"Hamid","family":"Emamekhoo","sequence":"additional","affiliation":[{"name":"University of Wisconsin, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-5975","authenticated-orcid":false,"given":"M. Hassan","family":"Murad","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Celano","sequence":"additional","affiliation":[{"name":"Greater Baltimore Medical Center (GBMC), Towson, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry M.","family":"Kungel","sequence":"additional","affiliation":[{"name":"Woolwich, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Hentzen","sequence":"additional","affiliation":[{"name":"Leawood, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-8035","authenticated-orcid":false,"given":"Michael Thomas","family":"Serzan","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3372-7914","authenticated-orcid":false,"given":"Rahul A.","family":"Parikh","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center, Westwood, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_11_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.5_suppl.LBA18"},{"key":"e_1_3_11_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2024-CT231"},{"key":"e_1_3_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.05.011"},{"key":"e_1_3_11_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.4_suppl.18"},{"key":"e_1_3_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00209-8"},{"key":"e_1_3_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.05.007"},{"key":"e_1_3_11_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-24-01283"},{"key":"e_1_3_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2025.04.012"},{"key":"e_1_3_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01653-2"},{"key":"e_1_3_11_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00007"},{"key":"e_1_3_11_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00542"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO-25-02693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:03:08Z","timestamp":1786114988000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-25-02693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,2,20]]}},"alternative-id":["10.1200\/JCO-25-02693"],"URL":"https:\/\/doi.org\/10.1200\/jco-25-02693","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1200\/GDL.26.0120","asserted-by":"subject"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]},"assertion":[{"value":"2025-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}