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Obesity and metabolic dysfunction are well-known factors that promote the development, progression, and resistance to therapy in various cancers, suggesting that drugs targeting these pathways may have anticancer effects. Emerging epidemiologic and clinical evidence shows that GLP-1RA therapy is linked to a lower risk of several obesity-related cancers, including GI, breast, endometrial, ovarian, prostate, and hematologic malignancies. Mechanistic studies also reveal effects on insulin signaling, long-term inflammation, angiogenesis, and immune system modulation. This comprehensive review integrates current knowledge of GLP-1RAs in cancer care, covering drug action, epidemiology, underlying mechanisms, and clinical application. We evaluate evidence for cancer prevention, their use as complementary treatments, and outcomes in patients with existing cancer. Overall, the evidence suggests that GLP-1RAs could become a novel class of agents linking metabolic health and cancer therapy, with potential applications in neoadjuvant treatment strategies, particularly in settings where prolonged neoadjuvant intervals allow for metabolic optimization before definitive surgical intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-26-00062","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:59:17Z","timestamp":1782763157000},"page":"2244-2252","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Metabolic Modulation in Cancer Care: The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists"],"prefix":"10.1200","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-3431","authenticated-orcid":false,"given":"Hugo C.","family":"Temperley","sequence":"first","affiliation":[{"name":"Department of Radiology, St James's Hospital, Dublin, Ireland"},{"name":"Trinity St James's Cancer Institute, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-6411","authenticated-orcid":false,"given":"Michael E.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Trinity St James's Cancer Institute, Dublin, Ireland"},{"name":"Discipline of Surgery, School of Medicine, Trinity College Dublin - University of Dublin, Ireland"},{"name":"Department of Surgery, St James Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01438-6"},{"key":"e_1_3_5_3_2","first-page":"65","article-title":"Mechanisms linking excess adiposity and carcinogenesis promotion","volume":"5","author":"P\u00e9rez-Hern\u00e1ndez AI","year":"2014","unstructured":"P\u00e9rez-Hern\u00e1ndez AI, Catal\u00e1n V, G\u00f3mez-Ambrosi J, et al: Mechanisms linking excess adiposity and carcinogenesis promotion. 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