{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:58:34Z","timestamp":1790369914014,"version":"4.1.0"},"reference-count":5,"publisher":"American Society of Clinical Oncology (ASCO)","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"abstract":"\n The phase III CEPHEUS trial (ClinicalTrials.gov identifier:\n NCT03652064<\/jats:ext-link>\n ) of patients with transplant-ineligible (TIE) or transplant-deferred newly diagnosed multiple myeloma (NDMM; N = 395) demonstrated improved overall minimal residual disease (MRD) negativity rates among patients achieving \u2265complete response and progression-free survival (PFS) with daratumumab plus bortezomib, lenalidomide, and dexamethasone (DVRd) versus VRd. We present efficacy and safety outcomes in the CEPHEUS TIE subgroup (N = 289; DVRd, n = 144; VRd, n = 145). Patients were either age 18-70 years with \u22651 comorbidity likely to negatively affect tolerability of high-dose chemotherapy with autologous stem cell transplantation or age \u226570 years. At a median follow-up of 58.7 months, the MRD negativity rate (10\n \u22125<\/jats:sup>\n ) was 60.4% (DVRd) versus 39.3% (VRd;\n P<\/jats:italic>\n = .0004). Rates of sustained MRD negativity (10\n \u22125<\/jats:sup>\n ) for \u226512 months (47.2%\n v<\/jats:italic>\n 28.3%;\n P<\/jats:italic>\n = .0010) and \u226524 months (40.3%\n v<\/jats:italic>\n 22.8%;\n P<\/jats:italic>\n = .0015) were significantly higher with DVRd. Risk of disease progression or death was 49% lower for DVRd versus VRd (hazard ratio [HR], 0.51 [95% CI, 0.35 to 0.74];\n P<\/jats:italic>\n = .0003). Although immature, overall survival favored DVRd (HR, 0.66 [95% CI, 0.42 to 1.03]). Adverse events were consistent with known safety profiles. This analysis demonstrates that the deep responses achieved with DVRd translate into improved PFS in patients with TIE NDMM, reinforcing DVRd as a standard of care.\n <\/jats:p>","DOI":"10.1200\/jco-26-00401","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:59:18Z","timestamp":1790366358000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Daratumumab Plus Bortezomib, Lenalidomide, and Dexamethasone in Newly Diagnosed Multiple Myeloma: Transplant-Ineligible Subgroup Analysis of CEPHEUS"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-8731","authenticated-orcid":false,"given":"Saad Z.","family":"Usmani","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-8460","authenticated-orcid":false,"given":"Thierry","family":"Facon","sequence":"additional","affiliation":[{"name":"University of Lille, CHU Lille, Service des Maladies du Sang, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4327-1957","authenticated-orcid":false,"given":"Vania","family":"Hungria","sequence":"additional","affiliation":[{"name":"Cl\u00ednica M\u00e9dica S\u00e3o Germano, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-7034","authenticated-orcid":false,"given":"Nizar J.","family":"Bahlis","sequence":"additional","affiliation":[{"name":"Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Venner","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada"},{"name":"BC Cancer\u2014Vancouver Centre, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0859-7257","authenticated-orcid":false,"given":"Marc","family":"Braunstein","sequence":"additional","affiliation":[{"name":"Perlmutter Cancer Center, NYU Langone Health, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-7009","authenticated-orcid":false,"given":"Ludek","family":"Pour","sequence":"additional","affiliation":[{"name":"University Hospital Brno, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Marti","sequence":"additional","affiliation":[{"name":"Hospital Universitario M\u00fatua de Terrassa, Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2206-4796","authenticated-orcid":false,"given":"Supratik","family":"Basu","sequence":"additional","affiliation":[{"name":"Royal Wolverhampton NHS Trust and University of Wolverhampton, CRN West Midlands, NIHR, Wolverhampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-7287","authenticated-orcid":false,"given":"Yael C.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky (Ichilov) Medical Center, Tel Aviv, Israel"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"National Hospital Organization Shibukawa Medical Center, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Hulin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Haut L\u00e9v\u00eaque, University Hospital, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-1050","authenticated-orcid":false,"given":"Sebastian","family":"Grosicki","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-5248","authenticated-orcid":false,"given":"Wojciech","family":"Legiec","sequence":"additional","affiliation":[{"name":"St John of Dukla Oncology Center of Lublin Land, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-8657","authenticated-orcid":false,"given":"Meral","family":"Beksac","sequence":"additional","affiliation":[{"name":"Istinye University, Ankara Liv Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-9548","authenticated-orcid":false,"given":"Angelo","family":"Maiolino","sequence":"additional","affiliation":[{"name":"Instituto Americas de Ensino, Pesquisa e Inova\u00e7\u00e3o, Rio de Janeiro, Brazil"},{"name":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Kanazawa University Hospital, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-8689","authenticated-orcid":false,"given":"Aurore","family":"Perrot","sequence":"additional","affiliation":[{"name":"CHU de Toulouse, IUCT-O, Universit\u00e9 de Toulouse, UPS, Service d\u2019H\u00e9matologie, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-0232","authenticated-orcid":false,"given":"Mehmet","family":"Turgut","sequence":"additional","affiliation":[{"name":"Ondokuz May\u0131s University Faculty of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wang","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Krevvata","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3842-9042","authenticated-orcid":false,"given":"Jaclyn","family":"Stanziola","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Loi","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie M.J.","family":"Van Brummelen","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Lopez-Masi","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Rowe","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, High Wycombe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L.","family":"Carson","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-1820","authenticated-orcid":false,"given":"Sonja","family":"Zweegman","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312054"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817249"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03485-7"},{"key":"e_1_3_10_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2400712"},{"key":"e_1_3_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05522-2"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO-26-00401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:59:18Z","timestamp":1790366358000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-26-00401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":5,"alternative-id":["10.1200\/JCO-26-00401"],"URL":"https:\/\/doi.org\/10.1200\/jco-26-00401","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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