{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:16:26Z","timestamp":1788560186005,"version":"build-2803163510"},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"26","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,9,10]]},"abstract":"\n \n \n The COMBI-I trial (ClinicalTrials.gov identifier:\n NCT02967692<\/jats:ext-link>\n ) evaluating spartalizumab plus dabrafenib and trametinib (sparta-DabTram, n = 267) versus placebo plus dabrafenib and trametinib (placebo-DabTram, n = 265) for\n BRAF<\/jats:italic>\n V600\u2013mutant unresectable or metastatic melanoma failed to reach its primary end point of progression-free survival at 24 months. This final analysis reports overall survival (OS) during at least 5 years of extended follow-up. At the end of the trial (August 21, 2024), the median duration of follow-up was 76.9 months (range, 73.7-83.3 months). The median OS was 61.5 months (95% CI, 41.6 to not evaluable) for the sparta-DabTram arm and 41.6 months (95% CI, 30.6 to 56.9) for the placebo-DabTram arm (hazard ratio, 0.760 [95% CI, 0.598 to 0.966]). The safety findings were consistent with the known safety profile for sparta-DabTram. The most common treatment-related adverse event (TRAE) was pyrexia (65.9%\n v<\/jats:italic>\n 46.2%, respectively, in the two study arms). Grade \u22653 TRAEs were reported in 57.3% and 36.7% of patients in the two arms, respectively. The combination of sparta-DabTram appears to improve OS compared with dabrafenib and trametinib alone in patients with\n BRAF<\/jats:italic>\n V600\u2013mutant metastatic melanoma.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/jco-26-00528","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:00:10Z","timestamp":1786564810000},"page":"2490-2495","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["COMBI-I: Long-Term Overall Survival With Spartalizumab Plus Dabrafenib and Trametinib in\n BRAF<\/i>\n V600\u2013Mutant Advanced Melanoma"],"prefix":"10.1200","volume":"44","clinical-trial-number":[{"clinical-trial-number":"nct02967692","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-8458","authenticated-orcid":false,"given":"Antoni","family":"Ribas","sequence":"first","affiliation":[{"name":"University of California Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9493-0238","authenticated-orcid":false,"given":"Caroline","family":"Robert","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Oncologique, Gustave Roussy, Villejuif, France"},{"name":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm, Biomarqueurs Pr\u00e9dicteurs et nouvelles Strat\u00e9gies Mol\u00e9culaires en Th\u00e9rapeutique Anticanc\u00e9reuse, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-7858","authenticated-orcid":false,"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[{"name":"University Hospital Essen, National Center for Tumor Diseases (NCT-West), German Cancer Consortium, Both Campus Essen, and University Alliance Ruhr, Research Center One Health, University Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-3545","authenticated-orcid":false,"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"The Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-851X","authenticated-orcid":false,"given":"Hussein","family":"Tawbi","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-0478","authenticated-orcid":false,"given":"Keith","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-475X","authenticated-orcid":false,"given":"Paolo A.","family":"Ascierto","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy"},{"name":"Istituto Nazionale Tumori IRCCS Fondazione \u201cG. 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