{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:49:31Z","timestamp":1791413371874,"version":"4.3.3"},"reference-count":150,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,10,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Immunomodulatory drugs (IMiDs) have fundamentally reshaped multiple myeloma therapy, extending survival and establishing durable backbones across induction, relapse, and maintenance. Cereblon's identification as a druggable E3 ligase substrate receptor created the mechanistic path to next-generation modulators, whereas widespread frontline lenalidomide exposure created the clinical need for scalable oral agents active in IMiD-refractory, triple-class\u2013exposed disease. In this review, we link the clinical evolution of the IMiD class to its mechanistic foundation. We trace the path from thalidomide's serendipitous repurposing to lenalidomide's establishment of the Rd backbone and maintenance paradigm and to pomalidomide's ability to retain efficacy after lenalidomide failure. We integrate structural and biochemical insights showing how medicinal chemistry reshaped cereblon engagement and selective neosubstrate degradation, producing tumor-intrinsic and immune-mediated effects. We then focus on next-generation cereblon E3 ligase modulators (CELMoDs), including iberdomide and mezigdomide, designed to deepen cereblon modulation and overcome resistance. We summarize early clinical experience and ongoing randomized programs, discuss rational combinations with monoclonal antibodies, bispecific T-cell engagers, and chimeric antigen receptor T-cell therapies, and propose a pragmatic framework for positioning CELMoDs in an immunotherapy-rich treatment era.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-26-00545","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:00:09Z","timestamp":1789070409000},"page":"2848-2864","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in Multiple Myeloma: 30 Years in the Making"],"prefix":"10.1200","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0243-4040","authenticated-orcid":false,"given":"Abdul-Hamid","family":"Bazarbachi","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Columbia University Irving Medical Center\/New York-Presbyterian Hospital, New York, NY"},{"name":"Sorbonne University, INSERM UMRs 938, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-7344","authenticated-orcid":false,"given":"Suzanne","family":"Lentzsch","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Columbia University Irving Medical Center\/New York-Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Facon","sequence":"additional","affiliation":[{"name":"H\u00e9matologie Clinique, Centre Hospitalier Universitaire de Lille, Uni Lille, INSERM U1286, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Harousseau","sequence":"additional","affiliation":[{"name":"Institut Canc\u00e9rologique de l'Ouest, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7264-808X","authenticated-orcid":false,"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"Sorbonne University, INSERM UMRs 938, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-279893"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116129"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911183412102"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177319"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244851"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244917"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01921"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01928"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2874"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.66"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0572"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.07.019"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2022.167457"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.add7574"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025861"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09994-w"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008676"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101571"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.285636"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12708"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-625004"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0620-4"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.9.4082"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101584"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-187748"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025030873"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025030891"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00168-7"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1336"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0828"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.188227"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017010348"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-221077"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14610"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16979"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007081"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-698092"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.217943"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-207917"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-436"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12157"},{"key":"e_1_3_5_43_2","article-title":"EZH2 inhibition overcomes immunomodulatory drug resistance in multiple myeloma via a cereblon-dependent pathway","author":"Li Y","unstructured":"Li Y, Wilson A, Chrisochoidou Y, et al: EZH2 inhibition overcomes immunomodulatory drug resistance in multiple myeloma via a cereblon-dependent pathway. Haematologica 10.3324\/haematol.2025.288024 [epub ahead of print on February 12, 2026]","journal-title":"Haematologica"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00657-1"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08304.x"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-140954"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03142.x"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00250-4"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1323"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015909"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070594"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070596"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.147"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1841-y"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2817"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303487"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70284-0"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402551"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-795047"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.120121"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112704"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679415"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.6679"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.120790"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30687-9"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.07.030"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01740"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2013.38"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-356063"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-611426"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.6802"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-452375"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-538835"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70380-2"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.137083"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-700872"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16213"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30152-4"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008866"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2024.2322030"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32556-5"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00128-5"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805762"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00218-1"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2024.07.014"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.07.010"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2025.105514"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403407"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-025-01041-x"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-02587"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2026.0001"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312054"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00263-0"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817249"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03485-7"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03050-2"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2400712"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30323-9"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024027620"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0620-8"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124298"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-137710"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-137667"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025029215"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0038"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(23)01793-7"},{"key":"e_1_3_5_107_2","volume-title":"30th European Hematology Association (EHA) Congress","author":"Aleman A","year":"2025","unstructured":"Aleman A, Amatangelo M, Grossman L, et al: Iberdomide (IBER) treatment enhances manufactured CAR T cell expansion and functionality and is immunostimulatory in patients post-CAR T cell therapy. 30th European Hematology Association (EHA) Congress. Milan, Italy, European Hematology Association, 2025"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(21)02087-5"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00290-3"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-158180"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-200187"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-5841"},{"key":"e_1_3_5_113_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-251"},{"key":"e_1_3_5_114_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-249"},{"key":"e_1_3_5_115_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-100"},{"key":"e_1_3_5_116_2","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2025.2501920"},{"key":"e_1_3_5_117_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-199016"},{"key":"e_1_3_5_118_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-2255"},{"key":"e_1_3_5_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(25)02560-1"},{"key":"e_1_3_5_120_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.7532"},{"key":"e_1_3_5_121_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-5810"},{"key":"e_1_3_5_122_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.7553"},{"key":"e_1_3_5_123_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-177564"},{"key":"e_1_3_5_124_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-101"},{"key":"e_1_3_5_125_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-4048"},{"key":"e_1_3_5_126_2","unstructured":"Reference deleted"},{"key":"e_1_3_5_127_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-2289"},{"key":"e_1_3_5_128_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124338"},{"key":"e_1_3_5_129_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124345"},{"key":"e_1_3_5_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(22)00560-2"},{"key":"e_1_3_5_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bneo.2025.100179"},{"key":"e_1_3_5_132_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-178881"},{"key":"e_1_3_5_133_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-5699"},{"key":"e_1_3_5_134_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-157987"},{"key":"e_1_3_5_135_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303194"},{"key":"e_1_3_5_136_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.7539"},{"key":"e_1_3_5_137_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-137161"},{"key":"e_1_3_5_138_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-5697"},{"key":"e_1_3_5_139_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-174443"},{"key":"e_1_3_5_140_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-198408"},{"key":"e_1_3_5_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(23)01446-5"},{"key":"e_1_3_5_142_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.TPS8070"},{"key":"e_1_3_5_143_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-198403"},{"key":"e_1_3_5_144_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-4010"},{"key":"e_1_3_5_145_2","unstructured":"Reference deleted"},{"key":"e_1_3_5_146_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-5835"},{"key":"e_1_3_5_147_2","unstructured":"Reference deleted"},{"key":"e_1_3_5_148_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-5807"},{"key":"e_1_3_5_149_2","unstructured":"Reference deleted"},{"key":"e_1_3_5_150_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-025-02787-9"},{"key":"e_1_3_5_151_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2514663"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO-26-00545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:00:25Z","timestamp":1791410425000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-26-00545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":150,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2026,10,10]]}},"alternative-id":["10.1200\/JCO-26-00545"],"URL":"https:\/\/doi.org\/10.1200\/jco-26-00545","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}