{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:50:46Z","timestamp":1791319846399,"version":"4.3.1"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"abstract":"\n PURPOSE<\/jats:title>\n This trial evaluated whether the addition of sitagliptin to antithymocyte globulin (ATG)\u2013based prophylaxis reduces the incidence of acute graft-versus-host disease (aGVHD) after alternative donor hematopoietic stem-cell transplantation.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n This prospective, multicenter, open-label, randomized trial enrolled patients age 18-60 years with hematologic malignancies who received myeloablative conditioning haploidentical or unrelated donor transplantation. Participants were randomly assigned in a 1:1 ratio to ATG-based prophylaxis (ATG + calcineurin inhibitor + methotrexate + mycophenolate mofetil) with or without sitagliptin (600 mg orally once every 12 hours, days \u20131 to +14). The primary end point was the cumulative incidence of grade \u2161-\u2163 aGVHD by day +100.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n From December 22, 2021, to June 16, 2023, 190 of the 251 screened patients were enrolled, with a median follow-up of 29.8 (0.7-41.3) months. The sitagliptin group had a significantly lower incidence of grade \u2161-\u2163 aGVHD on day +100 (14.7%\n v<\/jats:italic>\n 31.6%; subdistribution hazard ratio [sHR] = 0.41;\n P<\/jats:italic>\n = .005). Reduced grade \u2162-\u2163 (6.3%\n v<\/jats:italic>\n 18.9%; sHR = 0.30;\n P<\/jats:italic>\n = .010) and intestinal aGVHD (12.6%\n v<\/jats:italic>\n 29.5%;\n P<\/jats:italic>\n = .004) and superior day +180 GVHD-free, relapse-free survival (GRFS; 86.3%\n v<\/jats:italic>\n 72.6%; HR = 0.44;\n P<\/jats:italic>\n = .016) were also observed. No between-group disparities were detected in 2-year chronic GVHD, nonrelapse mortality, relapse-free\/overall survival, or cytomegalovirus\/Epstein-Barr virus reactivation; the adverse event profiles were similar.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n In this randomized trial, adjunct sitagliptin to ATG-containing prophylaxis significantly reduced the incidence of grade \u2161-\u2163 aGVHD. Reductions in severe and intestinal aGVHD, as well as improved day +180 GRFS, were exploratory observations; no significant benefits were detected for long-term GRFS, overall survival, or RFS, and treatment did not alter the engraftment, relapse, or infection risk.<\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/jco-26-00670","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:59:07Z","timestamp":1791316747000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Sitagliptin for Acute Graft-Versus-Host Disease Prevention in Alternative Donor Transplantation: A Randomized Phase III Trial"],"prefix":"10.1200","clinical-trial-number":[{"clinical-trial-number":"nct05149365","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1424-1862","authenticated-orcid":false,"given":"Man","family":"Qiao","sequence":"first","affiliation":[{"name":"National Clinical 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