{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:06:22Z","timestamp":1789596382281,"version":"build-2803163510"},"reference-count":17,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"27","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,9,20]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The TRIANGLE trial established an ibrutinib-containing therapy without autologous stem-cell transplantation (ASCT) as the new standard for younger, treatment-na\u00efve patients with mantle cell lymphoma (MCL). However, the benefit of rituximab maintenance (RM) within this novel standard is unclear. We investigated whether RM improves progression-free survival (PFS) and overall survival (OS) with acceptable toxicity when added to the experimental arms of TRIANGLE. This secondary analysis of TRIANGLE included patients randomly assigned to ibrutinib-containing therapy without (I) or with (A + I) ASCT who responded to induction\/ASCT. RM was given per national and center practice. PFS and OS of patients with and without RM were compared with inverse probability of treatment weighted Kaplan-Meier curves and log-rank tests. Among responders after induction\/ASCT (I: 274; A + I: 237), RM was given to 61% (I) and 64% (A + I). RM prolonged PFS in ibrutinib-containing treatment arms (I: log-rank test:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .003, 4-year PFS probability RM\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      no RM, 85%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      73%; A + I:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001, 90%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      75%). There were trends toward prolonged OS in RM groups. RM groups were at higher risk of grade 3 to 5 infectious toxicity (I: 34%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      11%; A + I: 41%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      18%). Our findings support adding RM to BTK inhibitor treatments in younger, untreated patients with MCL to achieve prolonged remission.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-26-00705","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:00:09Z","timestamp":1784059209000},"page":"2582-2589","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Rituximab Maintenance Added to Ibrutinib-Containing Therapy in Younger, Untreated Patients With Mantle Cell Lymphoma: Results From the TRIANGLE Trial"],"prefix":"10.1200","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8283-2681","authenticated-orcid":false,"given":"Marco","family":"Ladetto","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale and SCDU Ematologia AOU Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3948-6186","authenticated-orcid":false,"given":"Katja","family":"Gutmair","sequence":"additional","affiliation":[{"name":"Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Pettenkofer School of Public Health, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-7806","authenticated-orcid":false,"given":"Rita","family":"Tavarozzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale and SCDU Ematologia AOU Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pawlikowski","sequence":"additional","affiliation":[{"name":"Department of Medicine III, LMU University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-0591","authenticated-orcid":false,"given":"Michael","family":"Schomaker","sequence":"additional","affiliation":[{"name":"Department of Statistics, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Munich Center for Machine Learning (MCML), Ludwig-Maximilians University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-0918","authenticated-orcid":false,"given":"Jeanette","family":"Doorduijn","sequence":"additional","affiliation":[{"name":"Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0532-1204","authenticated-orcid":false,"given":"Eva","family":"Gin\u00e9","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Cl\u00ednic de Barcelona, IDIBAPS, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-6707","authenticated-orcid":false,"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lund University and Skane University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-2674","authenticated-orcid":false,"given":"Jan","family":"Walewski","sequence":"additional","affiliation":[{"name":"Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-1741","authenticated-orcid":false,"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Haematology and Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Mey","sequence":"additional","affiliation":[{"name":"Oncology and Hematology, Kantonsspital Graubuenden, Chur, Switzerland"},{"name":"Swiss Cancer Institute (formerly Swiss Group for Clinical Cancer Research\u2014SAKK), Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Riise","sequence":"additional","affiliation":[{"name":"Department of Oncology, Oslo University Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-6073","authenticated-orcid":false,"given":"Marek","family":"Trneny","sequence":"additional","affiliation":[{"name":"First Faculty of Medicine, Charles University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-5600","authenticated-orcid":false,"given":"Vibeke K.J.","family":"Vergote","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7076-6501","authenticated-orcid":false,"given":"Netanel A.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"The Department of Hematology and BMT, Rambam Health Care Campus, Haifa, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2014Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-2450","authenticated-orcid":false,"given":"Maria","family":"Gomes da Silva","sequence":"additional","affiliation":[{"name":"Hematology Department, Instituto Portugues de Oncologia de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-511X","authenticated-orcid":false,"given":"Sirpa","family":"Lepp\u00e4","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-4236","authenticated-orcid":false,"given":"Linmiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Pettenkofer School of Public Health, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Stilgenbauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-2821","authenticated-orcid":false,"given":"Andrea","family":"Kerkhoff","sequence":"additional","affiliation":[{"name":"Medizinische Klinik A, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-7061","authenticated-orcid":false,"given":"Ron D.","family":"Jachimowicz","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Center for Integrated Oncology and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Max Planck Institute for Biology of Ageing, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"He\u00df","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Medical School of the Johannes Gutenberg-University, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van Meerten","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-9862","authenticated-orcid":false,"given":"Stefan","family":"Wirths","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology and Rheumatology, Center for Internal Medicine, University Hospital Tuebingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Herhaus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Technical University of Munich, School of Medicine and Health, TUM University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7642-2101","authenticated-orcid":false,"given":"Urban","family":"Novak","sequence":"additional","affiliation":[{"name":"Swiss Cancer Institute (formerly Swiss Group for Clinical Cancer Research\u2014SAKK), Bern, Switzerland"},{"name":"Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Dierlamm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, UKE Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"H\u00e4nel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hanoun","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sonnevi","sequence":"additional","affiliation":[{"name":"Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-0883","authenticated-orcid":false,"given":"Carlo","family":"Visco","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Integrata, Ematologia e Trapianto di midollo osseo and Department of 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