{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:08:15Z","timestamp":1791943695228,"version":"4.3.4"},"reference-count":8,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"18","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,6,20]]},"abstract":"<jats:p>\n                    <jats:boxed-text orientation=\"portrait\" position=\"float\" specific-use=\"update-notice\">\n                      <jats:p>\n                        <jats:bold>This guideline has been updated.<\/jats:bold>\n                      <\/jats:p>\n                      <jats:p>\n                        This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ascopubs.org\/guidelines\/therapy-stage-iv-non-small-cell-lung-cancer-without-driver-alterations\">online dynamic version<\/jats:ext-link>\n                        for the latest updates.\n                      <\/jats:p>\n                    <\/jats:boxed-text>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic toggle=\"yes\">Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the<\/jats:italic>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.asco.org\/practice-patients\/guidelines\/guideline-methodology\">\n                      <jats:italic toggle=\"yes\">ASCO Guidelines Methodology Manual<\/jats:italic>\n                    <\/jats:ext-link>\n                    <jats:italic toggle=\"yes\">. ASCO Living Guidelines follow the<\/jats:italic>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.asco.org\/about-asco\/legal\/conflict-interest-coi\">\n                      <jats:italic toggle=\"yes\">ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines<\/jats:italic>\n                    <\/jats:ext-link>\n                    <jats:italic toggle=\"yes\">\n                      . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information (\n                      <jats:xref ref-type=\"app\">Appendix 1<\/jats:xref>\n                      and\n                      <jats:xref ref-type=\"app\">Appendix 2<\/jats:xref>\n                      , online only). Updates are published regularly and can be found at\n                    <\/jats:italic>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ascopubs.org\/nsclc-non-da-living-guideline\">\n                      <jats:italic toggle=\"yes\">https:\/\/ascopubs.org\/nsclc-non-da-living-guideline<\/jats:italic>\n                    <\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1200\/jco-26-00842","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T19:59:13Z","timestamp":1779825553000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Therapy for Stage IV Non\u2013Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, 2026.3.1"],"prefix":"10.1200","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8764-4359","authenticated-orcid":false,"given":"Lyudmila","family":"Bazhenova","sequence":"first","affiliation":[{"name":"University of California San Diego Moores Cancer Center, San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1896","authenticated-orcid":false,"given":"Nofisat","family":"Ismaila","sequence":"additional","affiliation":[{"name":"American Society of Clinical Oncology (ASCO), Alexandria, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-745X","authenticated-orcid":false,"given":"Greg","family":"Durm","sequence":"additional","affiliation":[{"name":"Indiana University Health, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-7912","authenticated-orcid":false,"given":"Janet","family":"Freeman-Daily","sequence":"additional","affiliation":[{"name":"The ROS1ders, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-801X","authenticated-orcid":false,"given":"Hidehito","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2185-6368","authenticated-orcid":false,"given":"Gary R.","family":"MacVicar","sequence":"additional","affiliation":[{"name":"Illinois CancerCare, Peoria, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-3803","authenticated-orcid":false,"given":"Deebya Raj","family":"Mishra","sequence":"additional","affiliation":[{"name":"BP Koirala Institute of Health Sciences, Dharan, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-0202","authenticated-orcid":false,"given":"Bruna","family":"Pellini","sequence":"additional","affiliation":[{"name":"Miami Cancer Institute, Baptist Health South Florida, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-9948","authenticated-orcid":false,"given":"Erin L.","family":"Schenk","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Center, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8389-0701","authenticated-orcid":false,"given":"Navneet","family":"Singh","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-4602","authenticated-orcid":false,"given":"Natasha B.","family":"Leighl","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00824"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00825"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-02822"},{"key":"e_1_3_10_5_2","first-page":"e56","article-title":"Therapy for stage IV non\u2013small cell lung cancer without driver alterations: ASCO living guideline, 2026.3.0","volume":"40","author":"Reuss JE","year":"2026","unstructured":"Reuss JE, Bazhenova L, Ismaila N, et al: Therapy for stage IV non\u2013small cell lung cancer without driver alterations: ASCO living guideline, 2026.3.0. 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