{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:38:52Z","timestamp":1793335132666,"version":"4.5.0"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"22","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>\n                      Revumenib is an oral inhibitor of menin-KMT2A, a key dependency in acute myeloid leukemia (AML) with\n                      <jats:italic toggle=\"yes\">KMT2A<\/jats:italic>\n                      rearrangement (\n                      <jats:italic toggle=\"yes\">KMT2Ar<\/jats:italic>\n                      ),\n                      <jats:italic toggle=\"yes\">NPM1<\/jats:italic>\n                      mutation (\n                      <jats:italic toggle=\"yes\">NPM1mt<\/jats:italic>\n                      ), or\n                      <jats:italic toggle=\"yes\">NUP98<\/jats:italic>\n                      rearrangement (\n                      <jats:italic toggle=\"yes\">NUP98r<\/jats:italic>\n                      ). Preclinical studies suggest synergy with BCL2 inhibition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this phase I-II study, we evaluated an all-oral regimen of revumenib, decitabine\/cedazuridine, and venetoclax in patients 12 years and older with relapsed or refractory AML. Decitabine\/cedazuridine was given on days 1-5, venetoclax on days 1-14, and revumenib twice daily on days 1-28. The primary objectives were to determine the recommended phase II dose (RP2D) and to assess efficacy according to the composite complete remission (CRc) rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Forty-two patients were enrolled (median age, 40 years; range, 12-82) including 40% with\n                      <jats:italic toggle=\"yes\">KMT2Ar,<\/jats:italic>\n                      38% with\n                      <jats:italic toggle=\"yes\">NPM1mt<\/jats:italic>\n                      , and 21% with\n                      <jats:italic toggle=\"yes\">NUP98r.<\/jats:italic>\n                      Patients had a median of two prior lines of therapy; 52% had prior venetoclax. The RP2D of revumenib was 160 mg twice daily with a strong CYP3A4 inhibitor. Grade \u22653 adverse events included febrile neutropenia (36%), lung infection (21%), and thrombocytopenia (21%). Differentiation syndrome occurred in 10% (5% grade 3) and resolved with glucocorticoids. The CRc rate was 71%, and the CR or complete remission with partial hematologic recovery (CR\/CRh) rate was 60%, with measurable residual disease negativity by flow cytometry in 80% of these patients. The median duration of CR\/CRh for all patients was 10.5 months, not reached in\n                      <jats:italic toggle=\"yes\">KMT2Ar<\/jats:italic>\n                      , 10.7 months in\n                      <jats:italic toggle=\"yes\">NPM1mt<\/jats:italic>\n                      , and 5.9 months in\n                      <jats:italic toggle=\"yes\">NUP98r<\/jats:italic>\n                      . Emergent mutations in the menin-binding site occurred in 13%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This combination was associated with high response rates and durable remissions, with an acceptable safety, in heavily pretreated patients with AML harboring alterations susceptible to menin inhibition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco-26-01159","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:10:06Z","timestamp":1781158206000},"page":"2110-2120","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["All-Oral Combination of Revumenib, Decitabine, and Venetoclax for Relapsed or Refractory AML 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