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Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the<\/jats:italic>\n \n ASCO Guidelines Methodology Manual<\/jats:italic>\n <\/jats:ext-link>\n . ASCO Living Guidelines follow the<\/jats:italic>\n \n ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines<\/jats:italic>\n <\/jats:ext-link>\n \n . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information (\n Appendix 1<\/jats:xref>\n and\n Appendix 2<\/jats:xref>\n , online only). Updates are published regularly and can be found on the\n <\/jats:italic>\n \n ASCO Publications website<\/jats:italic>\n <\/jats:ext-link>\n .\n <\/jats:p>","DOI":"10.1200\/jco-26-01958","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:00:17Z","timestamp":1786996817000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Therapy for Stage IV Non\u2013Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.3"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-9767","authenticated-orcid":false,"given":"Paul","family":"Wheatley-Price","sequence":"first","affiliation":[{"name":"The Ottawa Hospital Research Institute\/University of Ottawa, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1896","authenticated-orcid":false,"given":"Nofisat","family":"Ismaila","sequence":"additional","affiliation":[{"name":"American Society of Clinical Oncology (ASCO), Alexandria, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-1947","authenticated-orcid":false,"given":"Antonio","family":"Calles Blanco","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Cetnar","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute, OHSU, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6270-4201","authenticated-orcid":false,"given":"Terri","family":"Conneran","sequence":"additional","affiliation":[{"name":"KRAS Kickers, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7715-4919","authenticated-orcid":false,"given":"Parth A.","family":"Desai","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-745X","authenticated-orcid":false,"given":"Greg","family":"Durm","sequence":"additional","affiliation":[{"name":"Indiana University Health, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-801X","authenticated-orcid":false,"given":"Hidehito","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humera","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Brown University Health, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6800-206X","authenticated-orcid":false,"given":"Swati","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Windsor Regional Cancer Program\/Western University, Windsor, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen Ashley","family":"Marrone","sequence":"additional","affiliation":[{"name":"John Hopkins Medical Center, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-665X","authenticated-orcid":false,"given":"Kirstin","family":"Perdrizet","sequence":"additional","affiliation":[{"name":"William Osler Health System, Brampton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8764-4359","authenticated-orcid":false,"given":"Lyudmila","family":"Bazhenova","sequence":"additional","affiliation":[{"name":"University of California, San Diego, San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00824"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00825"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-02825"},{"key":"e_1_3_9_5_2","doi-asserted-by":"crossref","unstructured":"Puri S Ismaila N Azar IH et al: Therapy for stage IV non\u2013small cell lung cancer with driver alterations: ASCO living guideline version 2026.3.2. 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