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In 2009, we published a consensus report to define prognostic factors, clinical subclassifications, treatment strategies, and response criteria. The 2009 consensus report has become the standard reference for clinical trials in ATL and a guide for clinical management. Since the last consensus there has been progress in the understanding of the molecular pathophysiology of ATL and risk-adapted treatment approaches. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Reflecting these advances, ATL researchers and clinicians joined together at the 18th International Conference on Human Retrovirology\u2014Human T-Lymphotropic Virus and Related Retroviruses\u2014in Tokyo, Japan, March, 2017, to review evidence for current clinical practice and to update the consensus with a new focus on the subtype classification of cutaneous ATL, CNS lesions in aggressive ATL, management of elderly or transplantation-ineligible patients, and treatment strategies that incorporate up-front allogeneic hematopoietic stem-cell transplantation and novel agents. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> As a result of lower-quality clinical evidence, a best practice approach was adopted and consensus statements agreed on by coauthors (&gt; 90% agreement). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> This expert consensus highlights the need for additional clinical trials to develop novel standard therapies for the treatment of ATL <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.18.00501","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T20:59:16Z","timestamp":1547845156000},"page":"677-687","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":254,"title":["Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report"],"prefix":"10.1200","volume":"37","author":[{"given":"Lucy B.","family":"Cook","sequence":"first","affiliation":[{"name":"Imperial College Healthcare National Health Service (NHS) Trust, London, United Kingdom"},{"name":"Imperial College London, London, United 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