{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:14:38Z","timestamp":1763018078858},"reference-count":39,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"36","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Vitamin D deficiency is described as a modifiable risk factor for the incidence of and mortality in many common cancers; however, data in Hodgkin lymphoma (HL) are lacking. <\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p> We thus performed a study measuring pretreatment vitamin D levels in prospectively treated patients with HL and correlated this with clinical outcomes. A total of 351 patients from the German Hodgkin Study Group clinical trials (HD7, HD8, and HD9) were included. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Fifty percent of patients were vitamin D deficient (&lt; 30 nmol\/L) before planned chemotherapy. Pretreatment vitamin D deficiency was more common in relapsed\/refractory patients than matched relapse-free controls (median baseline vitamin D, 21.4 nmol\/L v 35.5 nmol\/L; proportion with vitamin D deficiency, 68% v 41%; P &lt; .001). Vitamin D\u2013deficient patients had impaired progression-free survival (10-year difference, 17.6%; 95% CI, 6.9% to 28.4%; hazard ratio, 2.13; 95% CI, 1.84 to 2.48; P &lt; .001) and overall survival (10-year difference, 11.1%; 95% CI, 2.1% to 20.2%; hazard ratio, 1.82; 95% CI, 1.53 to 2.15; P &lt; .001), consistent across trials and treatment groups. We demonstrated that vitamin D status is an independent predictor of outcome and hypothesized that vitamin D status might be important for the chemosensitivity of HL. We subsequently performed experiments supplementing physiologic doses of vitamin D (calcitriol) to cultured HL cell lines and demonstrated increased antiproliferative effects in combination with chemotherapy. In an HL-xenograft animal model, we showed that supplemental vitamin D (dietary supplement, cholecalciferol) improves the chemosensitivity of tumors by reducing the rate of tumor growth compared with vitamin D or chemotherapy alone. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> On the basis of our clinical and preclinical findings, we encourage that vitamin D screening and replacement be incorporated into future randomized clinical trials to properly clarify the role of vitamin D replacement therapy in HL. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.19.00985","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T19:55:16Z","timestamp":1571342116000},"page":"3528-3537","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":29,"title":["Pretreatment Vitamin D Deficiency Is Associated With Impaired Progression-Free and Overall Survival in Hodgkin Lymphoma"],"prefix":"10.1200","volume":"37","author":[{"given":"Sven","family":"Borchmann","sequence":"first","affiliation":[{"name":"University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German Hodgkin Study Group, Cologne, Germany"},{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine, Cologne, Germany"},{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Else Kr\u00f6ner Forschungskolleg Clonal Evolution in Cancer, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melita","family":"Cirillo","sequence":"additional","affiliation":[{"name":"University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German Hodgkin Study Group, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Goergen","sequence":"additional","affiliation":[{"name":"University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German Hodgkin Study Group, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Meder","sequence":"additional","affiliation":[{"name":"University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German Hodgkin Study Group, Cologne, Germany"},{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Sasse","sequence":"additional","affiliation":[{"name":"University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn 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