{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:04:07Z","timestamp":1790309047253,"version":"4.1.0"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p> PURPOSE: Both paclitaxel and cisplatin have moderate activity in patients with metastatic or recurrent cancer of the cervix, and the combination of these two agents has shown activity and possible synergism in a variety of solid tumors. We administered this combination to patients with metastatic or recurrent cervical cancer to evaluate its activity. <\/jats:p><jats:p> PATIENTS AND METHODS: Thirty-four consecutive patients were treated on an outpatient basis with paclitaxel 175 mg\/m<jats:sup>2 <\/jats:sup>administered intravenously over a 3-hour period followed by cisplatin 75 mg\/m<jats:sup>2 <\/jats:sup>administered intravenously with granulocyte colony-stimulating factor support. The chemotherapy was administered every 3 weeks for a maximum of six courses. <\/jats:p><jats:p> RESULTS: Sixteen patients (47%; 95% confidence interval, 30% to 65%) achieved an objective response, including five complete responses and 11 partial responses. Responses occurred in 28% of patients with disease within the radiation field only and in 57% of patients with disease involving other sites. The median duration of response was 5.5 months, and the median times to progression and survival for all patients were 5 and 9 months, respectively. Grade 3 or 4 toxicities included anemia in 18% of patients and granulocytopenia in 15% of patients. Fifty-three percent of patients developed some degree of neurotoxicity; 21% of cases were grade 2 or worse. <\/jats:p><jats:p> CONCLUSION: The combination of paclitaxel with cisplatin seems relatively well tolerated and moderately active in patients with metastatic or recurrent cervical cancer. The significant incidence of neurotoxicity is of concern, and alternative methods of administration of the two agents could be evaluated. Then, further study of this combination, alone or with the addition of other active agents, is warranted. <\/jats:p>","DOI":"10.1200\/jco.1999.17.3.761","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T09:58:08Z","timestamp":1487930288000},"page":"761-761","source":"Crossref","is-referenced-by-count":88,"title":["Phase II Trial of Paclitaxel and Cisplatin in Metastatic and Recurrent Carcinoma of the Uterine Cervix"],"prefix":"10.1200","volume":"17","author":[{"given":"Christos A.","family":"Papadimitriou","sequence":"first","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyrillos","family":"Sarris","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia A.","family":"Moulopoulos","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Fountzilas","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Anagnostopoulos","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zannis","family":"Voulgaris","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Gika","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Giannakoulis","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Diakomanolis","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios A.","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Therapeutics, Gynecology, Radiation Oncology, and Radiology, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece; and Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1-0761","unstructured":"Thigpen  T,  Vance  R,  Khansur  T: Carcinoma of the uterine cervix: Current status and future directions.  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