{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:10:21Z","timestamp":1773144621745,"version":"3.50.1"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p> PURPOSE: Recent studies have suggested that the sentinel lymph node (SLN) biopsy is an accurate alternative staging procedure for women with breast cancer. The goal of this study was to identify a subset of breast cancer patients in whom metastatic disease was confined only to the SLN. <\/jats:p><jats:p> MATERIALS AND METHODS: From two institutions, we recruited 222 women with breast cancer for SLN biopsy. A SLN biopsy was performed in each patient, followed by an axillary dissection in 182 patients. Histologic and immunohistochemical cytokeratin stains were used on all SLNs. <\/jats:p><jats:p> RESULTS: The SLN was identified in 220 (97.8%) of the 225 biopsies. Evidence of metastatic breast cancer in the SLN was found in 60 (27.0%) of the 222 patients. Of these patients, 32 (53.3%) had evidence of tumor in the SLN only. By multivariate analysis, two factors were found to be significantly associated with a higher likelihood of tumor involvement in the non-SLNs: primary tumor size larger than 2.0 cm (P = .0004) and macrometastasis (&gt; 2.0 mm) in the SLN (P = .002). Additional analysis revealed that none (0%; 95% confidence interval, 0% to 18.5%) of the 18 patients with primary tumors \u2264 2.0 cm and micrometastasis to the SLN had remaining axillary lymph node involvement. <\/jats:p><jats:p> CONCLUSION: The primary tumor size and metastasis size in the SLN are independent factors in predicting the incidence of tumor in the non-SLNs. Therefore, the SLN biopsy alone may be adequate for staging and\/or therapy decision making in patients with primary breast tumors \u2264 2.0 cm and micrometastasis in the SLN. <\/jats:p>","DOI":"10.1200\/jco.1999.17.6.1720","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T06:13:07Z","timestamp":1487916787000},"page":"1720-1720","source":"Crossref","is-referenced-by-count":261,"title":["Sentinel Lymph Node Biopsy With Metastasis: Can Axillary Dissection Be Avoided in Some Patients With Breast Cancer?"],"prefix":"10.1200","volume":"17","author":[{"given":"Carol","family":"Reynolds","sequence":"first","affiliation":[{"name":"From the Departments of Laboratory Medicine and Pathology, and Surgery, Mayo Clinic, Rochester, MN; and Departments of Biostatistics and Epidemiology, Surgery, Radiology, and Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Mick","sequence":"additional","affiliation":[{"name":"From the Departments of Laboratory Medicine and Pathology, and Surgery, Mayo Clinic, Rochester, MN; 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