{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:49:21Z","timestamp":1764510561691},"reference-count":39,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p> PURPOSE: To analyze beta-integrin expression in non-Hodgkin's lymphomas (NHLs) in order to assess its distribution among histologic subtypes and correlate with clinical features and outcome. <\/jats:p><jats:p> PATIENTS AND METHODS: The expression of \u03b12 through \u03b16 and \u03b21 common chains of very late activation antigen (VLA ) molecules and \u03b1L (CD11a) and \u03b22 common (CD18) chains of leukocyte function-associated antigen 1 molecule were studied in 137 patients with NHL. Immunostaining was performed by a streptavidin-biotin alkaline phosphatase method, and integrin expression was semiquantitatively assessed. Correlation with clinical features was analyzed in 80 patients consecutively diagnosed as having immunocytoma (five cases), follicular lymphoma (19 cases), mantle-cell lymphoma (MCL; four cases), diffuse large-cell lymphoma (DLCL; 40 cases), lymphoblastic lymphoma (LL; six cases), anaplastic Ki-1\u2013positive lymphoma (one case), and other peripheral T-cell lymphoma (five cases). <\/jats:p><jats:p> RESULTS: MCL cells did not show \u03b12 and \u03b16 expression, whereas most expressed weak to moderate levels of \u03b13, \u03b14, and \u03b15. LL mostly showed \u03b12 to \u03b15 expression, whereas \u03b16 was observed in seven of 11 cases (higher proportion than that shown in other subgroups). Alpha chains of VLA molecules were present more frequently in T-cell than in B-cell lymphomas. Patients with moderate\/strong \u03b14, CD11a, and \u03b22 common chain expression presented more frequently with advanced stage and bone marrow infiltration. Moderate\/strong \u03b14, \u03b15, and \u03b21 common chain expression correlated with extranodal involvement. In the subset of B-cell DLCL patients, negative\/weak expression of \u03b13 and \u03b14 chains was related to a higher complete response rate. Moreover, negative or weak expression of \u03b12, \u03b13, \u03b14, and \u03b21<jats:sub> <\/jats:sub>common chain had favorable significance for overall and failure-free survivals. <\/jats:p><jats:p> CONCLUSION: In NHL, beta-integrin expression is related to histologic subtype. The expression pattern of these molecules probably influences disease dissemination and patients' prognoses. <\/jats:p>","DOI":"10.1200\/jco.1999.17.6.1869","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T06:13:07Z","timestamp":1487916787000},"page":"1869-1869","source":"Crossref","is-referenced-by-count":29,"title":["Expression of Beta-Integrin Adhesion Molecules in Non-Hodgkin's Lymphoma: Correlation With Clinical and Evolutive Features"],"prefix":"10.1200","volume":"17","author":[{"given":"Mar\u00eda-Jos\u00e9","family":"Terol","sequence":"first","affiliation":[{"name":"From the Hematopathology Unit, Departments of Hematology and Internal Medicine, Instituto de Investigaciones Biom\u00e9dicas \u201cAugust Pi i Sunyer,\u201d Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"L\u00f3pez-Guillermo","sequence":"additional","affiliation":[{"name":"From the Hematopathology Unit, Departments of Hematology and Internal Medicine, Instituto de Investigaciones Biom\u00e9dicas \u201cAugust Pi i Sunyer,\u201d Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Bosch","sequence":"additional","affiliation":[{"name":"From the Hematopathology Unit, Departments of Hematology and Internal Medicine, Instituto de Investigaciones Biom\u00e9dicas \u201cAugust Pi i Sunyer,\u201d Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neus","family":"Villamor","sequence":"additional","affiliation":[{"name":"From the Hematopathology Unit, Departments of Hematology and Internal Medicine, Instituto de Investigaciones Biom\u00e9dicas \u201cAugust Pi i Sunyer,\u201d Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda-Cinta","family":"Cid","sequence":"additional","affiliation":[{"name":"From the Hematopathology Unit, Departments of Hematology and Internal Medicine, Instituto de Investigaciones Biom\u00e9dicas \u201cAugust Pi i Sunyer,\u201d Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00edas","family":"Campo","sequence":"additional","affiliation":[{"name":"From the Hematopathology Unit, Departments of Hematology and Internal Medicine, Instituto de Investigaciones Biom\u00e9dicas \u201cAugust Pi i Sunyer,\u201d Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Montserrat","sequence":"additional","affiliation":[{"name":"From the Hematopathology Unit, Departments of Hematology and Internal Medicine, Instituto de Investigaciones Biom\u00e9dicas \u201cAugust Pi i Sunyer,\u201d Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1-1869","doi-asserted-by":"publisher","DOI":"10.1038\/346425a0"},{"key":"R2-1869","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90233-9"},{"key":"R3-1869","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90115-S"},{"key":"R4-1869","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002053"},{"key":"R5-1869","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80117-2"},{"key":"R6-1869","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400602"},{"key":"R7-1869","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.004003"},{"key":"R8-1869","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4682(10)80016-9"},{"key":"R9-1869","unstructured":"Horst  E,  Meijer  CJL,  Radoskiewicz  T, et al: Expression of a human homing receptor (CD44) in lymphoid malignancies and related stages of lymphoid development.  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