{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:52:59Z","timestamp":1773827579978,"version":"3.50.1"},"reference-count":32,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p> PURPOSE: In the International Lymphoma Study Group classification of lymphoma, extranodal marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) type is listed as a distinctive entity. However, nodal MZL is listed as a provisional entity because of questions as to whether it is truly a disease or just an advanced stage of MALT-type MZL. To resolve the issue of whether primary nodal MZL without involvement of mucosal sites exists and whether it is clinically different from extranodal MALT-type lymphoma, we compared the clinical features of these two lymphomas. <\/jats:p><jats:p> PATIENTS AND METHODS: Five expert hematopathologists reached a consensus diagnosis of MZL in 93 patients. Seventy-three were classified as having MALT-type MZL because of involvement of a mucosal site at the time of diagnosis, and 20 were classified as having nodal MZL because of involvement of lymph nodes without involvement of a mucosal site. <\/jats:p><jats:p> RESULTS: A comparison of the clinical features of nodal MZL and MALT-type MZL showed that more patients with nodal MZL presented with advanced-stage disease (71% v 34%; P = .02), peripheral lymphadenopathy (100% v 8%; P &lt; .001), and para-aortic lymphadenopathy (56% v 14%; P &lt; .001) than those with MALT-type MZL. However, fewer patients with nodal MZL had a large mass (\u2265 5 cm) than those with MALT-type MZL (31% v 68%; P = .03). The 5-year overall survival of patients with nodal MZL was lower than that for patients with MALT-type MZL (56% v 81%; P = .09), with a similar result for failure-free survival (28% v 65%; P = .01). Comparisons of patients with International Prognostic Index scores of 0 to 3 showed that those with nodal MZL had lower 5-year overall survival (52% v 88%; P = .025) and failure-free survival (30% v 75%; P = .007) rates than those with MALT-type MZL. <\/jats:p><jats:p> CONCLUSION: Nodal MZL seems to be a distinctive disease entity rather than an advanced stage of MALT-type MZL because the clinical presentations and survival outcomes are different in these two types of MZL. Clinically, nodal MZL is similar to other low-grade, node-based B-cell lymphomas, such as follicular and small lymphocytic lymphomas. <\/jats:p>","DOI":"10.1200\/jco.1999.17.8.2486","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T06:19:51Z","timestamp":1487917191000},"page":"2486-2486","source":"Crossref","is-referenced-by-count":150,"title":["Marginal Zone B-Cell Lymphoma: A Clinical Comparison of Nodal and Mucosa-Associated Lymphoid Tissue Types"],"prefix":"10.1200","volume":"17","author":[{"given":"Bharat N.","family":"Nathwani","sequence":"first","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Anderson","sequence":"additional","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James O.","family":"Armitage","sequence":"additional","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Cavalli","sequence":"additional","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Diebold","sequence":"additional","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton R.","family":"Drachenberg","sequence":"additional","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy L.","family":"Harris","sequence":"additional","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"MacLennan","sequence":"additional","affiliation":[{"name":"From the University of Southern California (USC) and Los Angeles County+USC Healthcare Network, Los Angeles, CA; University of Nebraska Medical Center, Omaha, NE; Ospedale San Giovanni, Bellinzona, Switzerland; Hotel Dieu de Paris, Paris, France; Harvard Medical School, Boston, MA; St James University, Leeds, United Kingdom; and University of W\u00fcrzburg, W\u00fcrzburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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