{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:01:11Z","timestamp":1790380871951,"version":"4.1.0"},"reference-count":46,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"26","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2020,9,10]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>The Children\u2019s Oncology Group (COG) protocol AALL0434 evaluated the safety and efficacy of multi-agent chemotherapy with Capizzi-based methotrexate\/pegaspargase (C-MTX) in patients with newly diagnosed pediatric T-cell lymphoblastic lymphoma (T-LL) and gained preliminary data using nelarabine in high-risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>The trial enrolled 299 patients, age 1-31 years. High-risk (HR) patients had \u2265 1% minimal detectable disease (MDD) in the bone marrow at diagnosis or received prior steroid treatment. Induction failure was defined as failure to achieve a partial response (PR) by the end of the 4-week induction. All patients received the augmented Berlin-Frankfurt-Muenster (ABFM) C-MTX regimen. HR patients were randomly assigned to receive or not receive 6 5-day courses of nelarabine incorporated into ABFM. Patients with induction failure were nonrandomly assigned to ABFM C-MTX plus nelarabine. No patients received prophylactic cranial radiation; however, patients with CNS3 disease (CSF WBC \u2265 5\/\u03bcL with blasts or cranial nerve palsies, brain\/eye involvement, or hypothalamic syndrome) were ineligible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      At end-induction, 98.8% of evaluable participants had at least a PR. The 4-year event-free survival (EFS) and overall survival (OS) were 84.7% \u00b1 2.3% and 89.0% \u00b1 2.0%. The 4-year disease-free survival (DFS) from end-induction was 85.9% \u00b1 2.6%. There was no difference in DFS observed between the HR and standard-risk groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .29) or by treatment regimen (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .55). Disease stage, tumor response, and MDD at diagnosis did not demonstrate thresholds that resulted in differences in EFS. Nelarabine did not show an advantage for HR patients. CNS relapse occurred in only 4 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>COG AALL0434 produced excellent outcomes in one of the largest trials ever conducted for patients with newly diagnosed T-LL. The COG ABFM regimen with C-MTX provided excellent EFS and OS without cranial radiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.20.00531","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T15:59:29Z","timestamp":1592409569000},"page":"3062-3070","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":72,"title":["Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children\u2019s Oncology Group AALL0434"],"prefix":"10.1200","volume":"38","author":[{"given":"Robert J.","family":"Hayashi","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology, Washington School of Medicine, St Louis Children\u2019s Hospital, St Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart S.","family":"Winter","sequence":"additional","affiliation":[{"name":"Children\u2019s Minnesota Cancer and Blood Disorders Program, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly P.","family":"Dunsmore","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine and Carilion Clinic, Roanoke, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children\u2019s Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent L.","family":"Wood","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Seattle Children\u2019s Hospital, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Hermiston","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UCSF Benioff Children\u2019s Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Teachey","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney R.","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Raetz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mignon L.","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UCSF Benioff Children\u2019s Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi J.","family":"Winick","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, University of Texas Southwestern\/Simmons Cancer Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Hunger","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, and The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Gross","sequence":"additional","affiliation":[{"name":"National Cancer Institute Center for Global Health, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Bollard","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation, Children\u2019s National Health System, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5827"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1270"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.07.011"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.203"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7661"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-474148"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1318"},{"key":"e_1_3_8_9_2","first-page":"416","article-title":"Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: A BFM group report","volume":"95","author":"Reiter A","year":"2000","unstructured":"Reiter A, Schrappe M, Ludwig WD, et al: Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: A BFM group report. Blood 95:416-421, 2000","journal-title":"Blood"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.02.011"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-008-0771-5"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.2707"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.400"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.3367"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25607"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25470"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.8724"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14874"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-018-0455-9"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4544"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.7250"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.10500"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401310"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-357-2_8"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.310"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_3_8_28_2","unstructured":"R Foundation: The R project for statistical computing. http:\/\/www.r-project.org"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14877"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23502"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24198"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000788"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex082"},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07765.x"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0808"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0164"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07320.x"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.139162"},{"key":"e_1_3_8_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25469"},{"key":"e_1_3_8_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25824"},{"key":"e_1_3_8_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21941"},{"key":"e_1_3_8_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-292615"},{"key":"e_1_3_8_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24848"},{"key":"e_1_3_8_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25699"},{"key":"e_1_3_8_45_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.6545"},{"key":"e_1_3_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.03.004"},{"key":"e_1_3_8_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-487744"}],"updated-by":[{"DOI":"10.1200\/jco-25-02779","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000}}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.20.00531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T20:59:10Z","timestamp":1767646750000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.20.00531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":46,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2020,9,10]]}},"alternative-id":["10.1200\/JCO.20.00531"],"URL":"https:\/\/doi.org\/10.1200\/jco.20.00531","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"2020-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}