{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T09:33:55Z","timestamp":1794044035743,"version":"4.8.0"},"reference-count":16,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"\n PURPOSE<\/jats:title>\n As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19\u2013free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway.<\/jats:p>\n <\/jats:sec>\n \n PATIENTS AND METHODS<\/jats:title>\n This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19\u2013free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19\u2013free surgical pathways. Patients who underwent surgery within COVID-19\u2013free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19\u2013free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1\/2), propensity score\u2013matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19\u2013free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Within available resources, dedicated COVID-19\u2013free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.<\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/jco.20.01933","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T15:59:28Z","timestamp":1601999968000},"page":"66-78","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":168,"title":["Elective Cancer Surgery in COVID-19\u2013Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort 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