{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:55:29Z","timestamp":1780620929452,"version":"3.54.1"},"reference-count":32,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Patients with relapsed lymphomas often fail salvage therapies including high-dose chemotherapy and mono-antigen\u2013specific T-cell therapies, highlighting the need for nontoxic, novel treatments. To that end, we clinically tested an autologous T-cell product that targets multiple tumor-associated antigens (TAAs) expressed by lymphomas with the intent of treating disease and preventing immune escape. <\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p> We expanded polyclonal T cells reactive to five TAAs: PRAME, SSX2, MAGEA4, SURVIVIN, and NY-ESO-1. Products were administered to 32 patients with Hodgkin lymphomas (n = 14) or non-Hodgkin lymphomas (n = 18) in a two-part phase I clinical trial, where the objective of the first phase was to establish the safety of targeting all five TAAs (fixed dose, 0.5 \u00d7 10<jats:sup>7<\/jats:sup> cells\/m<jats:sup>2<\/jats:sup>) simultaneously and the second stage was to establish the maximum tolerated dose. Patients had received a median of three prior lines of therapy and either were at high risk for relapse (adjuvant arm, n = 17) or had chemorefractory disease (n = 15) at enrollment. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Infusions were safe with no dose-limiting toxicities observed in either the antigen- or dose-escalation phases. Although the maximum tolerated dose was not reached, the maximum tested dose at which efficacy was observed (two infusions, 2 \u00d7 10<jats:sup>7<\/jats:sup> cells\/m<jats:sup>2<\/jats:sup>) was determined as the recommended phase II dose. Of the patients with chemorefractory lymphomas, two (of seven) with Hodgkin lymphomas and four (of eight) with non-Hodgkin lymphomas achieved durable complete remissions (&gt; 3 years). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> T cells targeting five TAAs and administered at doses of up to two infusions of 2 \u00d7 10<jats:sup>7<\/jats:sup> cells\/m<jats:sup>2<\/jats:sup> are well-tolerated by patients with lymphoma both as adjuvant and to treat chemorefractory lymphoma. Preliminary indicators of antilymphoma activity were seen in the chemorefractory cohort across both antigen- and dose-escalation phases. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.20.02224","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T21:00:29Z","timestamp":1611867629000},"page":"1415-1425","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":46,"title":["T-Cell Therapy for Lymphoma Using Nonengineered Multiantigen-Targeted T Cells Is Safe and Produces Durable Clinical Effects"],"prefix":"10.1200","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7970-9391","authenticated-orcid":false,"given":"Spyridoula","family":"Vasileiou","sequence":"first","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-2331","authenticated-orcid":false,"given":"Premal D.","family":"Lulla","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifigeneia","family":"Tzannou","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manik","family":"Kuvalekar","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-0664","authenticated-orcid":false,"given":"Wendy L.","family":"Callejas","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinalini","family":"Bilgi","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-7160","authenticated-orcid":false,"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfen J.","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rammurti","family":"Kamble","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-7837","authenticated-orcid":false,"given":"Carlos A.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayne H.","family":"Rouce","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Gee","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bambi J.","family":"Grilley","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Vera","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Bollard","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm K.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-7698","authenticated-orcid":false,"given":"Helen E.","family":"Heslop","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3210-2864","authenticated-orcid":false,"given":"Cliona M.","family":"Rooney","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Leen","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Carrum","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxz202"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00443"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2589"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01342"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000905"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30864-7"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.09.009"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914347"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.11.004"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00146"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0442"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.183459"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.167"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040890"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-091280"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.5304"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-863654"},{"key":"b19","first-page":"1921","volume":"96","author":"Adida C","year":"2000","journal-title":"Blood"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.124909"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1159\/000381533"},{"key":"b22","first-page":"5847","volume":"8","author":"He C","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-379982"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.02.031"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006034"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490565"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008918"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2648"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110814108"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810114105"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25445"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2595"}],"updated-by":[{"DOI":"10.1200\/jco.21.02454","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000}},{"DOI":"10.1200\/jco.21.01212","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000}}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.20.02224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T10:34:04Z","timestamp":1653820444000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.20.02224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":32,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["10.1200\/JCO.20.02224"],"URL":"https:\/\/doi.org\/10.1200\/jco.20.02224","relation":{"correction":[{"id-type":"doi","id":"10.1200\/JCO.21.01212","asserted-by":"object"},{"id-type":"doi","id":"10.1200\/JCO.21.02454","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"2020-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}