{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:42:02Z","timestamp":1783471322913,"version":"3.55.0"},"reference-count":10,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:p> PURPOSE: : This study expands the existing limited data as to whether patients developing clinically significant paclitaxel-induced hypersensitivity reactions can continue to be treated with this important antineoplastic agent and how such retreatment might be undertaken. <\/jats:p><jats:p> PATIENTS AND METHODS: More than 450 patients received paclitaxel, either as a single agent or in a combination regimen, for a female pelvic malignancy in the Gynecologic Oncology Program of the Cleveland Clinic Cancer Center from January 1995 through December 1998. <\/jats:p><jats:p> RESULTS: Of the more than 450 patients, 44 (approximately 9%) developed at least one episode of a clinically relevant hypersensitivity reaction to the cytotoxic drug. All 43 individuals (plus an additional four patients referred to our center after having previously experienced a severe paclitaxel-associated hypersensitivity reaction at another institution) who were retreated with paclitaxel were ultimately able to receive the agent. Five patients required treatment with a standardized desensitization regimen, developed by our group, to successfully receive paclitaxel. <\/jats:p><jats:p> DISCUSSION: On the basis of this large single-institution study of paclitaxel-associated hypersensitivity reactions, we conclude that with appropriate precautions essentially all individuals experiencing these reactions can be safely treated with this agent. <\/jats:p>","DOI":"10.1200\/jco.2000.18.1.102","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T09:21:04Z","timestamp":1487928064000},"page":"102-102","source":"Crossref","is-referenced-by-count":157,"title":["Paclitaxel-Associated  Hypersensitivity Reactions:  Experience of the Gynecologic Oncology Program of the Cleveland Clinic Cancer  Center"],"prefix":"10.1200","volume":"18","author":[{"given":"Maurie","family":"Markman","sequence":"first","affiliation":[{"name":"From  the The Cleveland Clinic Taussig Cancer Center; and the Departments of  Gynecology\/Obstetrics and Hematology\/Medical OncologyThe Cleveland Clinic  Foundation, Cleveland,  OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kennedy","sequence":"additional","affiliation":[{"name":"From  the The Cleveland Clinic Taussig Cancer Center; and the Departments of  Gynecology\/Obstetrics and Hematology\/Medical OncologyThe Cleveland Clinic  Foundation, Cleveland,  OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Webster","sequence":"additional","affiliation":[{"name":"From  the The Cleveland Clinic Taussig Cancer Center; and the Departments of  Gynecology\/Obstetrics and Hematology\/Medical OncologyThe Cleveland Clinic  Foundation, Cleveland,  OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kulp","sequence":"additional","affiliation":[{"name":"From  the The Cleveland Clinic Taussig Cancer Center; and the Departments of  Gynecology\/Obstetrics and Hematology\/Medical OncologyThe Cleveland Clinic  Foundation, Cleveland,  OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrude","family":"Peterson","sequence":"additional","affiliation":[{"name":"From  the The Cleveland Clinic Taussig Cancer Center; and the Departments of  Gynecology\/Obstetrics and Hematology\/Medical OncologyThe Cleveland Clinic  Foundation, Cleveland,  OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Belinson","sequence":"additional","affiliation":[{"name":"From  the The Cleveland Clinic Taussig Cancer Center; and the Departments of  Gynecology\/Obstetrics and Hematology\/Medical OncologyThe Cleveland Clinic  Foundation, Cleveland,  OH."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1-0010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601043340101"},{"key":"R2-0010","doi-asserted-by":"crossref","unstructured":"Perez   EA:   Paclitaxel in breast  cancer.  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Oncologist 3:67,1998-85,","DOI":"10.1634\/theoncologist.3-2-67"},{"key":"R4-0010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504133321507"},{"key":"R5-0010","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.7.1263"},{"key":"R6-0010","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.5.885"},{"key":"R7-0010","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.12.2654"},{"key":"R8-0010","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.12.3517"},{"key":"R9-0010","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70281-6"},{"key":"R10-0010","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4906"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2000.18.1.102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:59:22Z","timestamp":1653515962000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2000.18.1.102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1,1]]}},"alternative-id":["10.1200\/JCO.2000.18.1.102"],"URL":"https:\/\/doi.org\/10.1200\/jco.2000.18.1.102","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1,1]]}}}