{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:38:22Z","timestamp":1790516302749,"version":"4.1.0"},"reference-count":44,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2000,8,16]]},"abstract":"<jats:p> PURPOSE: Patients who suffer from non\u2013small-cell lung cancer (NSCLC) with ipsilateral mediastinal lymph node involvement (N2) belong to a heterogeneous subgroup of patients. We analyzed the prognosis of patients with resected N2 NSCLC to propose homogeneous patient subgroups. <\/jats:p><jats:p> PATIENTS AND METHODS: The present study comprised 702 consecutive patients from six French centers who underwent surgical resection of N2 NSCLC. Initially, two groups of patients were defined: patients with clinical N2 (cN2) and those with minimal N2 (mN2) disease were patients in whom N2 disease was and was not detected preoperatively at computed tomographic scan, respectively. <\/jats:p><jats:p> RESULTS: The median duration of follow-up was 52 months (range, 18 to 120 months). A multivariate analysis using Cox regression identified four negative prognostic factors, namely, cN2 status (P &lt; .0001), involvement of multiple lymph node levels (L2+; P &lt; .0001), pT3 to T4 stage (P &lt; .0001), and no preoperative chemotherapy (P &lt; .01). For patients treated with primary surgery, 5-year survival rates were as follows: mN2, one level involved (mN2L1, n = 244): 34%; mN2, multiple level involvement (mN2L2+, n = 78): 11%; cN2L1 (n = 118): 8%; and cN2L2+ (n = 122): 3%. When only patients with mN2L1 disease were considered, the site of lymph node involvement according to the American Thoracic Society numbering system had no prognostic significance (P = .14). Preoperative chemotherapy was associated with a better prognosis for those with cN2 (P &lt; .0001). Five-year survival rates were 18% and 5% for cN2 patients treated with and without preoperative chemotherapy, respectively. <\/jats:p><jats:p> CONCLUSION: This study has identified homogeneous N2 NSCLC prognostic subgroups and suggests different therapeutic approaches according to the subgroup profile. <\/jats:p>","DOI":"10.1200\/jco.2000.18.16.2981","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T09:19:48Z","timestamp":1487927988000},"page":"2981-2989","source":"Crossref","is-referenced-by-count":409,"title":["Survival of Patients With Resected N2 Non\u2013Small-Cell Lung Cancer: Evidence for a Subclassification and Implications"],"prefix":"10.1200","volume":"18","author":[{"given":"Fabrice","family":"Andre","sequence":"first","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Grunenwald","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Pignon","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Dujon","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Louis","family":"Pujol","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Yves","family":"Brichon","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brouchet","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Quoix","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; Department of Pneumology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Westeel","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and BiostatisticsInstitut Gustave Roussy, Villejuif; Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris; Department of Thoracic Surgery, Clinique des C\u00e8dres, Bois Guillaume; Department of Thoracic Oncology, Hopital Arnaud de Villeneuve, Montpellier; Department of Thoracic Surgery, Hopital Michallon, Grenoble; Department of Thoracic Surgery, Hopital Purpan, Toulouse; Department of Pneumology, Hopital de Strasbourg, Strasbourg; 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