{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T19:28:55Z","timestamp":1772738935420,"version":"3.50.1"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p> PURPOSE: Anticancer drugs may induce acute mucosal injury to stomach and duodenum. This study was planned to evaluate the efficacy of omeprazole or ranitidine in preventing such an injury. <\/jats:p><jats:p> PATIENTS AND METHODS: Two hundred twenty-eight cancer patients with normal stomach and duodenum or with less than three erosions, who were selected to be treated with cyclophosphamide, methotrexate, and fluorouracil (90 breast carcinoma patients) or fluorouracil alone (138 colon carcinoma patients), were randomly assigned to treatment with omeprazole 20 mg, ranitidine 300 mg, or one placebo tablet a day. Seven days after the second course of chemotherapy (CT), the patients underwent a further esophagogastroduodenoscopy to evaluate the mucosal injury. Endoscopic findings were quantified on the basis of an arbitrary score, and the occurrence of epigastric pain or heartburn was assessed weekly. <\/jats:p><jats:p> RESULTS: A significant difference was found among the three groups (P = .0032), as well as between pre- and postCT endoscopic findings (P = .00001). Endoscopic scores after CT were significantly higher than pretreatment scores in the placebo (P = .003) and ranitidine (P = .003) groups but not in the omeprazole group (P = .354). Acute ulcers were significantly less frequent in patients receiving omeprazole or ranitidine than in those receiving placebo (P = .0001 and P = .0315, respectively). Epigastric pain and\/or heartburn were significantly less frequent in patients receiving omeprazole (P = .00124) or ranitidine (P = .038) than in those receiving placebo. <\/jats:p><jats:p> CONCLUSION: Omeprazole is effective in preventing chemotherapy-induced gastroduodenal injury. Ranitidine is effective in reducing the frequency of ulcers and upper gastrointestinal symptoms but is not effective in preventing the global endoscopic worsening caused by chemotherapy. The different efficacy of omeprazole and ranitidine can be explained by their different pharmacodynamics. <\/jats:p>","DOI":"10.1200\/jco.2000.18.3.463","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T07:04:24Z","timestamp":1487919864000},"page":"463-463","source":"Crossref","is-referenced-by-count":55,"title":["Randomized Trial of Omeprazole or Ranitidine Versus Placebo in the Prevention of Chemotherapy-Induced Gastroduodenal Injury"],"prefix":"10.1200","volume":"18","author":[{"given":"Sergio","family":"Sartori","sequence":"first","affiliation":[{"name":"From the Divisione di Medicina Interna e Oncologia MedicaAzienda Ospedaliera S Anna; Istituto di Medicina Interna II, Universit\u00e0 di Ferrara, Ferrara; and Servizio di Oncologia, Ospedale Civile, Rimini, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Trevisani","sequence":"additional","affiliation":[{"name":"From the Divisione di Medicina Interna e Oncologia MedicaAzienda Ospedaliera S Anna; Istituto di Medicina Interna II, Universit\u00e0 di Ferrara, Ferrara; and Servizio di Oncologia, Ospedale Civile, Rimini, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Nielsen","sequence":"additional","affiliation":[{"name":"From the Divisione di Medicina Interna e Oncologia MedicaAzienda Ospedaliera S Anna; Istituto di Medicina Interna II, Universit\u00e0 di Ferrara, Ferrara; and Servizio di Oncologia, Ospedale Civile, Rimini, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Tassinari","sequence":"additional","affiliation":[{"name":"From the Divisione di Medicina Interna e Oncologia MedicaAzienda Ospedaliera S Anna; Istituto di Medicina Interna II, Universit\u00e0 di Ferrara, Ferrara; and Servizio di Oncologia, Ospedale Civile, Rimini, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Panzini","sequence":"additional","affiliation":[{"name":"From the Divisione di Medicina Interna e Oncologia MedicaAzienda Ospedaliera S Anna; Istituto di Medicina Interna II, Universit\u00e0 di Ferrara, Ferrara; and Servizio di Oncologia, Ospedale Civile, Rimini, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Abbasciano","sequence":"additional","affiliation":[{"name":"From the Divisione di Medicina Interna e Oncologia MedicaAzienda Ospedaliera S Anna; Istituto di Medicina Interna II, Universit\u00e0 di Ferrara, Ferrara; and Servizio di Oncologia, Ospedale Civile, Rimini, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1-0078","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197810)42:4<1747::AID-CNCR2820420413>3.0.CO;2-T"},{"key":"R2-0078","doi-asserted-by":"publisher","DOI":"10.1159\/000226958"},{"key":"R3-0078","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199605)62:1<22::AID-JSO5>3.0.CO;2-T"},{"key":"R4-0078","doi-asserted-by":"publisher","DOI":"10.1007\/BF02282348"},{"key":"R5-0078","unstructured":"Van Schil  PE,  Brutel de la Riviere  A,  Knaepen  PJ, et al:  Second primary lung cancer after bronchial resection:  Treatment and results in eleven patients. J Thorac Cardiovasc Surg 104:1451,1992-1455,"},{"key":"R6-0078","doi-asserted-by":"crossref","unstructured":"Naunhein  KS,  Petruska  P,  Roy  TS, et al:  Preoperative chemotherapy and radiotherapy for esophageal carcinoma.  J Thorac Cardiovasc Surg 103:887,1992-893,","DOI":"10.1016\/S0022-5223(19)34912-8"},{"key":"R7-0078","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930815)72:4<1382::AID-CNCR2820720438>3.0.CO;2-Y"},{"key":"R8-0078","doi-asserted-by":"publisher","DOI":"10.1007\/BF01225690"},{"key":"R9-0078","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19961001)78:7<1477::AID-CNCR15>3.0.CO;2-X"},{"key":"R10-0078","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.43.41"},{"key":"R11-0078","unstructured":"Polloni  A,  Marchi  S,  Bellini  M, et al:  Use of antisecretory drugs for gastroprotection during antiblastic chemotherapy.  Drugs Exp Clin Res 11:303,1985-306,"},{"key":"R12-0078","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90002-3"},{"key":"R13-0078","unstructured":"Jewell  LD,  Fields  AL,  Murray  CJW:  Erosive gastroduodenitis with marked atypia after hepatic arterial infusion chemotherapy.  Am J Gastroenterol 80:421,1985-424,"},{"key":"R14-0078","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"R15-0078","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540567"},{"key":"R16-0078","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1012825"},{"key":"R17-0078","unstructured":"Sartori  S,  Trevisani  L,  Nielsen  I, et al:  Barrett\u2019s esophagus after continuous 5-fluorouracil infusion:  A case report. Gastrointest Cancer 2:163,1997-165,"},{"key":"R18-0078","doi-asserted-by":"crossref","unstructured":"Lubitz  L,  Ekert  H:  Reversible changes in duodenal mucosa associated with intensive chemotherapy followed by autologous marrow rescue.  Lancet 2:532,1979-533,","DOI":"10.1016\/S0140-6736(79)91595-2"},{"key":"R19-0078","doi-asserted-by":"crossref","unstructured":"Brinker  H:  Treatment of therapy-resistant acute myeloid leukemia with 7 and 8 cytostatics.  Scand J Haematol 14:35,1975-41,","DOI":"10.1111\/j.1600-0609.1975.tb00291.x"},{"key":"R20-0078","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010352"},{"key":"R21-0078","unstructured":"Lewis  JH:  Gastrointestinal toxicity due to medicinal agents.  Am J Gastroenterol 81:819,1986-834,"},{"key":"R22-0078","unstructured":"Mitchell  EP:  Gastrointestinal toxicity of chemotherapeutic agents.  Semin Oncol 5:566,1992-579,"},{"key":"R23-0078","unstructured":"Lewkow  L,  Hooker  J,  Raab  M, et al:  Phase I\u2013II study of dose-intensive mitoxantrone and cyclophosphamide with autologous bone-marrow transplantation in metastatic breast cancer.  Proc Am Soc Clin Oncol 9:98,1990  (abstr 145)"},{"key":"R24-0078","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.1.21"},{"key":"R25-0078","unstructured":"Duenas Gonzalez  A,  Sobrevilla Calvo  P,  Frias Mendivil  M, et al:  Misoprostol prophylaxis for high-dose chemotherapy-induced mucositis:  A randomized double-blind study. Bone Marrow Transplant 17:809,1996-812,"},{"key":"R26-0078","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050583"},{"key":"R27-0078","doi-asserted-by":"crossref","unstructured":"Lanzon-Miller  S,  Pounder  RE,  Hamilton  MR:  Twenty-four intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine or omeprazole.  Aliment Pharmacol Ther 1:239,1987-251,","DOI":"10.1111\/j.1365-2036.1987.tb00623.x"},{"key":"R28-0078","unstructured":"Olbe  L,  Cederberg  C,  Lind  T, et al:  Effect of omeprazole on gastric acid secretion and plasma gastrin.  J Gastroenterol Hepatol 4:19,1989-25,   (suppl 2)"},{"key":"R29-0078","doi-asserted-by":"crossref","unstructured":"Chiverton  SG,  Hunt  RH:  Relationship between inhibition of acid secretion and healing of peptic ulcers.  Scand J Gastroenterol 166:43,1989-47,   (suppl 1)","DOI":"10.3109\/00365528909091243"},{"key":"R30-0078","doi-asserted-by":"publisher","DOI":"10.1159\/000200896"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2000.18.3.463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:38:04Z","timestamp":1653514684000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2000.18.3.463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2,1]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,2,1]]}},"alternative-id":["10.1200\/JCO.2000.18.3.463"],"URL":"https:\/\/doi.org\/10.1200\/jco.2000.18.3.463","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2,1]]}}}