{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:13:38Z","timestamp":1790784818897,"version":"4.1.0"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2000,2,14]]},"abstract":"<jats:p> PURPOSE: We report the clinical features and treatment of 31 patients with a diagnosis of enteropathy-type intestinal T-cell lymphoma treated at the Wessex Regional Medical Oncology Unit in Southampton between 1979 and 1996 (23 men, eight women). <\/jats:p><jats:p> PATIENTS AND METHODS: Patients were identified from our lymphoma database. Details of history, physical examination, staging investigations, treatment, and outcome were taken from patient records. <\/jats:p><jats:p> RESULTS: Twelve patients (35%) had a documented clinical history of adult-onset celiac disease, and a further three had histologic features consistent with celiac disease in resected areas of the small bowel not infiltrated with lymphoma. After diagnosis, 24 (77%) of the 31 patients were treated with chemotherapy; the remaining seven had surgical treatment alone. More than half were unable to complete their planned chemotherapy courses, often because of poor nutritional status; 12 patients required enteral or parenteral feeding. A response to initial chemotherapy was observed in 14 patients (complete response, n = 10; partial response, n = 4). Observed complications of treatment were gastrointestinal bleeding, small-bowel perforation, and the development of enterocolic fistulae. Relapses occurred 1 to 60 months from diagnosis in 79% of those who responded to initial therapy. Of the total 31 patients, 26 (84%) have died, all from progressive disease or from complications of the disease and\/or its treatment. The actuarial 1- and 5-year survival rates are 38.7% and 19.7%, respectively, with 1- and 5-year failure-free survival rates of 19.4% and 3.2%, respectively. <\/jats:p><jats:p> CONCLUSION: The prognosis for these patients is poor. This, in part, reflects late diagnosis and poor performance status at the time of presentation. The role of salvage treatments and high-dose chemotherapy at relapse is not clear. However, it is encouraging that there are five long-term survivors in our patient population. <\/jats:p>","DOI":"10.1200\/jco.2000.18.4.795","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T07:02:08Z","timestamp":1487919728000},"page":"795-795","source":"Crossref","is-referenced-by-count":296,"title":["Enteropathy-Type Intestinal T-Cell Lymphoma: Clinical Features and Treatment of 31 Patients in a Single Center"],"prefix":"10.1200","volume":"18","author":[{"given":"Joanna","family":"Gale","sequence":"first","affiliation":[{"name":"From the Cancer Research Campaign Wessex Medical Oncology UnitRoyal South Hants Hospital, Southampton, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Simmonds","sequence":"additional","affiliation":[{"name":"From the Cancer Research Campaign Wessex Medical Oncology UnitRoyal South Hants Hospital, Southampton, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham M.","family":"Mead","sequence":"additional","affiliation":[{"name":"From the Cancer Research Campaign Wessex Medical Oncology UnitRoyal South Hants Hospital, Southampton, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Sweetenham","sequence":"additional","affiliation":[{"name":"From the Cancer Research Campaign Wessex Medical Oncology UnitRoyal South Hants Hospital, Southampton, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis H.","family":"Wright","sequence":"additional","affiliation":[{"name":"From the Cancer Research Campaign Wessex Medical Oncology UnitRoyal South Hants Hospital, Southampton, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R2-0113","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008278706002"},{"key":"R3-0113","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199305000-00001"},{"key":"R4-0113","unstructured":"Gull  W:  Fatty stools from disease of the mesenteric glands.  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