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All but one newly diagnosed patient with HCC had previously received systemic chemotherapy.<\/jats:p><jats:p>RESULTS: All patients with HB and HCC responded to HACE, as measured by imaging studies and alpha-fetoprotein levels. Surgical resection (complete or microscopic residual disease) was feasible in five of 11 patients, and three patients remain alive with no evidence of disease. Elevated liver transaminase and bilirubin levels were seen after each one of the 46 courses of HACE. Other toxicities included fever, pain, nausea, vomiting, and transient coagulopathy.<\/jats:p><jats:p>CONCLUSION: HACE is feasible, well tolerated, and effective in inducing surgical resectability of primary hepatic tumors in children.<\/jats:p>","DOI":"10.1200\/jco.2000.18.6.1279","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T07:16:39Z","timestamp":1487920599000},"page":"1279-1284","source":"Crossref","is-referenced-by-count":87,"title":["Feasibility and Toxicity of Chemoembolization for Children With Liver Tumors"],"prefix":"10.1200","volume":"18","author":[{"given":"Marcio H.","family":"Malogolowkin","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics and RadiologyUniversity of Southern California School of Medicine, and Division of Hematology\/Oncology, University of California Los Angeles, Los Angeles, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Stanley","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and RadiologyUniversity of Southern California School of Medicine, and Division of Hematology\/Oncology, University of California Los Angeles, Los Angeles, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Steele","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and RadiologyUniversity of Southern California School of Medicine, and Division of Hematology\/Oncology, University of California Los Angeles, Los Angeles, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Ortega","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and RadiologyUniversity of Southern California School of Medicine, and Division of Hematology\/Oncology, University of California Los Angeles, Los Angeles, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1-0175","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.12.2167"},{"key":"R2-0175","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820915)50:6<1061::AID-CNCR2820500607>3.0.CO;2-Q"},{"key":"R3-0175","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(75)90095-0"},{"key":"R4-0175","unstructured":"Clatworthy HW, Schiller M, Grosfeld JL: Primary liver tumors in infancy and childhood. 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