{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:39:20Z","timestamp":1768473560718,"version":"3.49.0"},"reference-count":48,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2000,5,9]]},"abstract":"<jats:p> PURPOSE: Children with acute lymphoblastic leukemia (ALL) and high hyperdiploidy (&gt; 50 chromosomes) have improved outcome compared with other ALL patients. We sought to identify cytogenetic features that would predict differences in outcome within this low-risk subset of ALL patients. <\/jats:p><jats:p> MATERIALS AND METHODS: High-hyperdiploid ALL patients (N = 480) were enrolled between 1988 and 1995 on Children\u2019s Cancer Group (CCG) trials. Karyotypes were determined by conventional banding. Treatment outcome was analyzed by life-table methods. <\/jats:p><jats:p> RESULTS: Patients with 54 to 58 chromosomes had better outcome than patients with 51 to 53 or 59 to 68 chromosomes (P = .0002). Patients with a trisomy of chromosome 10 (P &lt; .0001), chromosome 17 (P = .0002), or chromosome 18 (P = .004) had significantly improved outcome compared with their counterparts who lacked the given trisomy. Patients with a trisomy of chromosome 5 had worse outcome than patients lacking this trisomy (P = .02). Patients with trisomies of both chromosomes 10 and 17 had better outcome than those with a trisomy of chromosome 10 (P = .09), a trisomy of chromosome 17 (P = .01), or neither trisomy (P &lt; .0001). Multivariate analysis indicated that trisomy of chromosome 10 (P = .001) was the most significant prognostic factor for high-hyperdiploid patients, yet trisomy of chromosome 17 (P = .02) or chromosome 5 (P = .01) and modal chromosome number (P = .02) also had significant multivariate effects. <\/jats:p><jats:p> CONCLUSION: Trisomy of chromosomes 10 and 17 as well as modal chromosome number 54 to 58 identify subgroups of patients with high-hyperdiploid ALL who have a better outcome than high-hyperdiploid patients who lack these cytogenetic features. Trisomy of chromosome 5 confers poorer outcome among high-hyperdiploid patients. <\/jats:p>","DOI":"10.1200\/jco.2000.18.9.1876","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T07:20:01Z","timestamp":1487920801000},"page":"1876-1887","source":"Crossref","is-referenced-by-count":149,"title":["Prognostic Impact of Trisomies of Chromosomes 10, 17, and 5 Among Children With Acute Lymphoblastic Leukemia and High Hyperdiploidy (&gt; 50 Chromosomes)"],"prefix":"10.1200","volume":"18","author":[{"given":"Nyla A.","family":"Heerema","sequence":"first","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harland N.","family":"Sather","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha G.","family":"Sensel","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond J.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Nachman","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly J.","family":"Lange","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Steinherz","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce C.","family":"Bostrom","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory H.","family":"Reaman","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; Department of Hematology-Oncology, Children\u2019s Health Care, Minneapolis, MN; Department of Preventive Medicine, University of Southern California, and Department of Pediatric Hematology-Oncology, Children\u2019s Hospital, Los Angeles; Group Operations Center, Children\u2019s Cancer Group, Arcadia, CA; Department of Pediatric Hematology-Oncology, University of Michigan,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Gaynon","sequence":"additional","affiliation":[{"name":"From the Department of GeneticsHughes Institute, and Children\u2019s Cancer Group Acute Lymphoblastic Leukemia Biology Reference Laboratory, St. Paul; 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