{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:39:59Z","timestamp":1790192399946,"version":"4.1.0"},"reference-count":27,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:p> PURPOSE: To study feasibility and efficacy of a new salvage regimen in patients with relapsed and\/or refractory germ cell tumors. <\/jats:p><jats:p> PATIENTS AND METHODS: Between May 1995 and February 1997, 80 patients were entered onto a phase II study. Conventional-dose salvage treatment with three cycles of paclitaxel 175 mg\/m<jats:sup>2<\/jats:sup>, ifosfamide 5 \u00d7 1.2 g\/m<jats:sup>2<\/jats:sup>, and cisplatin 5 \u00d7 20 mg\/m<jats:sup>2<\/jats:sup> (TIP) was followed by one cycle of high-dose chemotherapy (HDCT) with carboplatin 500 mg\/m<jats:sup>2<\/jats:sup> \u00d7 3, etoposide 600 mg\/m<jats:sup>2<\/jats:sup> \u00d7 4, and thiotepa 150 to 250 mg\/m<jats:sup>2<\/jats:sup> \u00d7 3 (CET). In 23 patients, one additional cycle of paclitaxel 175 mg\/m<jats:sup>2<\/jats:sup> and ifosfamide 5 g\/m<jats:sup>2<\/jats:sup> (TI) was given immediately before TIP to improve stem-cell mobilization. <\/jats:p><jats:p> RESULTS: Fifty-five (69%) of 80 patients responded to TIP, 24 (30%) of 80 patients had stable disease (n = 5) or tumor progression (n = 19), and one patient died. Only 62 (78%) of 80 patients received subsequent HDCT. Among those, 41 (66%) of 62 patients responded and 20 (32%) of 62 patients had stable disease (n = 3) or tumor progression (n = 17). One patient died after HDCT from multiorgan failure. Survival probabilities at 3 years were 30% for overall and 25% for event-free survival. Peripheral neurotoxicity with sensorimotor impairment grade 2 through 4 in 29%, paresthesias grade 2 through 4 in 24%, and skin toxicity grade 2 through 3 in 15% of patients were the most relevant side effects. <\/jats:p><jats:p> CONCLUSION: Treatment with TIP followed by high-dose CET is feasible and can induce long-term remissions in 25% of patients with relapsed or refractory germ cell tumors. Peripheral nervous toxicity in approximately one third of patients is a disadvantage of this salvage strategy. <\/jats:p>","DOI":"10.1200\/jco.2001.19.1.81","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T06:54:02Z","timestamp":1487919242000},"page":"81-88","source":"Crossref","is-referenced-by-count":121,"title":["Salvage Treatment With Paclitaxel, Ifosfamide, and Cisplatin Plus High-Dose Carboplatin, Etoposide, and Thiotepa Followed by Autologous Stem-Cell Rescue in Patients With Relapsed or Refractory Germ Cell Cancer"],"prefix":"10.1200","volume":"19","author":[{"given":"O.","family":"Rick","sequence":"first","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bokemeyer","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Beyer","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. T.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Schwella","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kingreen","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Neureither","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Metzner","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Casper","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wandt","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Oncology, Charit\u00e9, Campus Virchow Klinikum, Berlin; Eberhard-Karls Universit\u00e4t, T\u00fcbingen; St\u00e4dtische Kliniken, Oldenburg; Universit\u00e4t Rostock, Rostock; Klinikum Nord, N\u00fcrnberg, Universit\u00e4t des Saarlandes, Homburg; Martin Luther Universit\u00e4t, Halle; Johannes Gutenberg Universit\u00e4t, Mainz; Klinikum Grosshadern, M\u00fcnchen; and Universit\u00e4t M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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