{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:12:28Z","timestamp":1791335548543,"version":"4.3.1"},"reference-count":36,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p> PURPOSE: Recommended surveillance for BRCA1 and BRCA2 mutation carriers includes regular mammography and clinical breast examination, although the effectiveness of these screening techniques in mutation carriers has not been established. The purpose of the present study was to compare breast magnetic resonance imaging (MRI) with ultrasound, mammography, and physical examination in women at high risk for hereditary breast cancer. <\/jats:p><jats:p> PATIENTS AND METHODS: A total of 196 women, aged 26 to 59 years, with proven BRCA1 or BRCA2 mutations or strong family histories of breast or ovarian cancer underwent mammography, ultrasound, MRI, and clinical breast examination on a single day. A biopsy was performed when any of the four investigations was judged to be suspicious for malignancy. <\/jats:p><jats:p> RESULTS: Six invasive breast cancers and one noninvasive breast cancer were detected among the 196 high-risk women. Five of the invasive cancers occurred in mutation carriers, and the sixth occurred in a woman with a previous history of breast cancer. The prevalence of invasive or noninvasive breast cancer in the 96 mutation carriers was 6.2%. All six invasive cancers were detected by MRI, all were 1.0 cm or less in diameter, and all were node-negative. In contrast, only three invasive cancers were detected by ultrasound, two by mammography, and two by physical examination. The addition of MRI to the more commonly available triad of mammography, ultrasound, and breast examination identified two additional invasive breast cancers that would otherwise have been missed. <\/jats:p><jats:p> CONCLUSION: Breast MRI may be superior to mammography and ultrasound for the screening of women at high risk for hereditary breast cancer. <\/jats:p>","DOI":"10.1200\/jco.2001.19.15.3524","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T07:28:07Z","timestamp":1487921287000},"page":"3524-3531","source":"Crossref","is-referenced-by-count":395,"title":["Comparison of Breast Magnetic Resonance Imaging, Mammography, and Ultrasound for Surveillance of Women at High Risk for Hereditary Breast Cancer"],"prefix":"10.1200","volume":"19","author":[{"given":"E.","family":"Warner","sequence":"first","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. B.","family":"Plewes","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Shumak","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. C.","family":"Catzavelos","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. S.","family":"Di Prospero","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Yaffe","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Goel","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ramsay","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Chart","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. E.C.","family":"Cole","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cutrara","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"Samuels","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Murphy","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Narod","sequence":"additional","affiliation":[{"name":"From the Divisions of Medical and Preventive Oncology, Departments of Medical Biophysics, Medical Imaging, Pathology, and Surgery, and Centre for Research in Women\u2019s Health, Sunnybrook and Women\u2019s College Health Sciences Centre; Department of Clinical Biochemistry, Toronto Hospital; and Department of Health Administration, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1-092628","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"R2-092628","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.5.1642"},{"key":"R3-092628","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400201"},{"key":"R4-092628","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.17.1475"},{"key":"R5-092628","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.18.1371"},{"key":"R6-092628","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540360065034"},{"key":"R7-092628","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950401)75:7<1619::AID-CNCR2820750711>3.0.CO;2-T"},{"key":"R8-092628","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<449::AID-CNCR13>3.0.CO;2-Q"},{"key":"R9-092628","unstructured":"Miller  AB,   Baines  CJ,   To  T,  et al:   Canadian National Breast Screening Study:  1. Breast cancer detection and death rates among women aged 40-49 years.   CMAJ 147:  1459,1992-1476,"},{"key":"R10-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.170.3.2916021"},{"key":"R11-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.1.2648479"},{"key":"R12-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.196.3.7644617"},{"key":"R13-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.2.8475297"},{"key":"R14-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.190.2.8284404"},{"key":"R15-092628","doi-asserted-by":"crossref","unstructured":"Brasch  RC,   Weinmann  HJ,   Wesbey  GE:   Contrast-enhanced NMR imaging:  Animal studies using gadolinium DTPA complex.   Am J Radiol 142:  625,1984-630,","DOI":"10.2214\/ajr.142.3.625"},{"key":"R16-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.154.3.3969477"},{"key":"R17-092628","doi-asserted-by":"crossref","unstructured":"Greeman  RL,   Lenkinski  RE,   Schnall  MD:   Bilateral imaging using separate interleaved 3D volumes and dynamical switched multiple receive coil arrays.  Magn Reson Imaging 39:  108,1998-115,","DOI":"10.1002\/mrm.1910390117"},{"key":"R18-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.1.8090928"},{"key":"R20-092628","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/41\/5\/007"},{"key":"R21-092628","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.9.670"},{"key":"R22-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.1.r99ap38101"},{"key":"R23-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.196.1.7784555"},{"key":"R26-092628","unstructured":"Berger  U,   Wilson  P,   Thethi  S,  et al:   Comparison of an immunocytochemical assay for progesterone receptor with biochemical method of measurement and immunocytochemical examination of the relationship between progesterone and estrogen receptors.  Cancer Res 49:  5176,1989-5179,"},{"key":"R27-092628","doi-asserted-by":"publisher","DOI":"10.1038\/nm0297-227"},{"key":"R28-092628","doi-asserted-by":"publisher","DOI":"10.1126\/science.3798106"},{"key":"R29-092628","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.11.845"},{"key":"R30-092628","doi-asserted-by":"publisher","DOI":"10.1007\/BF00666038"},{"key":"R31-092628","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520260071035"},{"key":"R32-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.2.9807581"},{"key":"R33-092628","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950515)75:10<2507::AID-CNCR2820751017>3.0.CO;2-H"},{"key":"R34-092628","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.13.1081"},{"key":"R35-092628","doi-asserted-by":"crossref","unstructured":"Chang  J,   Yang  WT,   Choo  HF:   Mammography in Asian patients with BRCA1 mutations.  Lancet 353:  2070,1999-2071,","DOI":"10.1016\/S0140-6736(05)77887-9"},{"key":"R36-092628","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960215)77:4<697::AID-CNCR16>3.0.CO;2-W"},{"key":"R37-092628","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199401000-00019"},{"key":"R38-092628","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.215.1.r00ap01267"},{"key":"R39-092628","doi-asserted-by":"publisher","DOI":"10.1054\/brst.2000.0135"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2001.19.15.3524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:44:59Z","timestamp":1653515099000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2001.19.15.3524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,1]]},"references-count":36,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2001,8,1]]}},"alternative-id":["10.1200\/JCO.2001.19.15.3524"],"URL":"https:\/\/doi.org\/10.1200\/jco.2001.19.15.3524","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,1]]}}}