{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:49:38Z","timestamp":1790880578696,"version":"4.1.0"},"reference-count":52,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:p> PURPOSE: To analyze clinical outcome and significant prognostic factors for overall (OS) and time to treatment failure (TTF) in a group of 494 patients with Hodgkin\u2019s disease (HD) undergoing autologous stem-cell transplantation (ASCT). <\/jats:p><jats:p> PATIENTS AND METHODS: Detailed records from the Grupo Espa\u00f1ol de Linfomas\/Transplante Aut\u00f3logo de M\u00e9dula \u00d3sea Spanish Cooperative Group Database on 494 HD patients who received an ASCT between January 1984 and May 1998 were reviewed. Two hundred ninety-eight males and 196 females with a median age of 27 years (range, 1 to 63 years) received autografts while in complete remission (n = 203) or when they had sensitive disease (n = 206) or resistant disease (n = 75) at a median time of 26 months (range, 4 to 259 months) after diagnosis. Most patients received high-dose chemotherapy without radiation for conditioning (n = 443). The graft consisted of bone marrow (n = 244) or peripheral blood (n = 250). <\/jats:p><jats:p> RESULTS: The 100-day mortality rate was 9%. The 5-year actuarial TTF and OS rates were 45.0% (95% confidence interval [CI], 39.5% to 50.5%) and 54.5% (95% CI, 48.4% to 60.6%), respectively. In multivariate analysis, the presence of active disease at transplantation, transplantation before 1992, and two or more lines of therapy before transplantation were adverse prognostic factors for outcome. Sixteen patients developed a secondary malignancy (5-year cumulative incidence of 4.3%) after transplantation. Adjuvant radiotherapy before transplantation, the use of total-body irradiation (TBI) in the conditioning regimen, and age \u2265 40 years were found to be predictive factors for the development of second cancers after ASCT. <\/jats:p><jats:p> CONCLUSION: ASCT achieves long-term disease-free survival in HD patients. Disease status before ASCT is the most important prognostic factor for final outcome; thus, transplantation should be considered in early stages of the disease. TBI must be avoided in the conditioning regimen because of a significantly higher rate of late complications, including secondary malignancies. <\/jats:p>","DOI":"10.1200\/jco.2001.19.5.1395","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T08:08:14Z","timestamp":1487923694000},"page":"1395-1404","source":"Crossref","is-referenced-by-count":188,"title":["Autologous Stem-Cell Transplantation for Hodgkin\u2019s Disease: Results and Prognostic Factors in 494 Patients From the Grupo Espa\u00f1ol de Linfomas\/Transplante Aut\u00f3logo de M\u00e9dula \u00d3sea Spanish Cooperative Group"],"prefix":"10.1200","volume":"19","author":[{"given":"A.","family":"Sureda","sequence":"first","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Arranz","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa 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Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Jarque","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Caballero","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ferr\u00e0","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garc\u00eda-Lara\u00f1a","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Carrera","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Ruiz-Romero","sequence":"additional","affiliation":[{"name":"From the Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret, Barcelona, 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