{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:43:14Z","timestamp":1791286994192,"version":"4.1.0"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2002,5,15]]},"abstract":"<jats:p>PURPOSE: The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma is associated with metastasis.<\/jats:p><jats:p>PATIENTS AND METHODS: CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metastases and six sentinel lymph node metastases). Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard regression analysis adjusted for standard prognostic indicators were performed to assess the prognostic relevance of CEACAM1 expression.<\/jats:p><jats:p>RESULTS: A total of 28 of 40 patients with CEACAM1-positive primary melanomas developed metastatic disease, compared with only six of 60 patients with CEACAM1-negative melanomas. Often, the strongest CEACAM1 expression was observed at the invading front. In addition, CEACAM1 expression was preserved in the metastatic lesions. Kaplan-Meier analysis revealed a highly significant association between CEACAM1 expression and metastasis (P &lt; .0001); multivariate Cox regression analysis, including CEACAM1 expression status adjusted for tumor thickness, presence of ulceration, and mitotic rate, confirmed that CEACAM1 is an independent factor for the risk of metastasis and demonstrated that the predictive value of CEACAM1 expression is superior to that of tumor thickness.<\/jats:p><jats:p>CONCLUSION: Expression of the cell adhesion molecule CEACAM1 in the primary tumors in melanoma patients is associated with the subsequent development of metastatic disease. This raises the possibility of a functional role for this cell adhesion molecule in the metastatic spread it indicates.<\/jats:p>","DOI":"10.1200\/jco.2002.05.033","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:13:48Z","timestamp":1027775628000},"page":"2530-2536","source":"Crossref","is-referenced-by-count":154,"title":["CEACAM1 Expression in Cutaneous Malignant Melanoma Predicts the Development of Metastatic Disease"],"prefix":"10.1200","volume":"20","author":[{"given":"Anka","family":"Thies","sequence":"first","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Moll","sequence":"additional","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Berger","sequence":"additional","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wagener","sequence":"additional","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Br\u00fcmmer","sequence":"additional","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Schulze","sequence":"additional","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Brunner","sequence":"additional","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Schumacher","sequence":"additional","affiliation":[{"name":"From the Institute for Anatomy, Dermatological Hospital, Institute for Mathematics and Computer Science in Medicine, Department of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, and the Departments of Dermatology and Cancer Research, Fachklinik Hornheide, University of M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1-108372","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950515)75:10<2499::AID-CNCR2820751016>3.0.CO;2-8"},{"key":"R2-108372","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92039-I"},{"key":"R3-108372","unstructured":"Natalie P, Nicotra MR, Cavaliere RS, et al: Differential expression of intercellular adhesion molecule 1 in primary and metastatic melanoma lesions. Cancer Res 50: 1271,1990-1278,"},{"key":"R4-108372","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<769::AID-IJC26>3.0.CO;2-#"},{"key":"R5-108372","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711670205"},{"key":"R6-108372","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.1860050510"},{"key":"R7-108372","doi-asserted-by":"publisher","DOI":"10.1177\/44.1.8543780"},{"key":"R8-108372","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500705"},{"key":"R9-108372","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10744"},{"key":"R10-108372","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700055"},{"key":"R11-108372","unstructured":"Bamberger AM, Riethdorf L, Nollau P, et al: Dysregulated expression of CD66a (BGP, C-CAM), an adhesion molecule of the CEA family, in endometrial cancer. Am J Pathol 152: 1401,1998-6,"},{"key":"R12-108372","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050071"},{"key":"R13-108372","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010601)91:11<2110::AID-CNCR1239>3.0.CO;2-Q"},{"key":"R14-108372","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000715)89:2<236::AID-CNCR5>3.0.CO;2-0"},{"key":"R15-108372","doi-asserted-by":"crossref","unstructured":"Stoffel A, Neumaier M, Gaida FJ, et al: Monoclonal, anti-domain and anti-peptide antibodies assign the molecular weight 160,000 granulocyte membrane antigen of the CD66 cluster to mRNA species encoded by the biliary glycoprotein gene, a member of the carcinoembryonic antigene family. J Immunol 150: 4978,1993-4984,","DOI":"10.4049\/jimmunol.150.11.4978"},{"key":"R16-108372","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640180005001"},{"key":"R17-108372","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.568"},{"key":"R18-108372","doi-asserted-by":"crossref","unstructured":"Balch CM, Buzaid AC, Atkins MB, et al: A new American Joint Committee on Cancer staging system for cutaneous melanoma. Cancer 88: 1486,2000-1491,","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1484::AID-CNCR29>3.0.CO;2-D"},{"key":"R19-108372","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1997.tb00479.x"},{"key":"R20-108372","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1673"},{"key":"R21-108372","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1996.0242"},{"key":"R22-108372","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2391::AID-CNCR14>3.0.CO;2-I"},{"key":"R23-108372","doi-asserted-by":"crossref","unstructured":"Huang J, Hardy JD, Sun Y, et al: Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J Cell Sci 112: 4193,1999-4205,","DOI":"10.1242\/jcs.112.23.4193"},{"key":"R25-108372","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90828-9"},{"key":"R26-108372","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80426-8"},{"key":"R27-108372","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.5026"},{"key":"R28-108372","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.1.65"},{"key":"R29-108372","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65730-6"},{"key":"R30-108372","unstructured":"Natali PG, Hamby CV, Felding-Habermann B, et al: Clinical significance of alpha(v)beta3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions. Cancer Res 57: 1554,1997-1560,"},{"key":"R31-108372","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61725-7"},{"key":"R32-108372","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64985-1"},{"key":"R33-108372","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3664::AID-IMMU3664>3.0.CO;2-D"},{"key":"R34-108372","doi-asserted-by":"publisher","DOI":"10.1002\/path.988"},{"key":"R35-108372","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65173-5"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2002.05.033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T20:37:23Z","timestamp":1682282243000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2002.05.033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,15]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2002,5,15]]}},"alternative-id":["10.1200\/JCO.2002.05.033"],"URL":"https:\/\/doi.org\/10.1200\/jco.2002.05.033","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,15]]}}}