{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:21:40Z","timestamp":1772814100305,"version":"3.50.1"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2002,9,15]]},"abstract":"<jats:p> PURPOSE: As chemotherapy has not been extensively studied in patients with lymphoma of the mucosa-associated lymphoid tissue (MALT), we initiated a prospective study to evaluate the activity of the nucleoside analog cladribine (2-chlorodeoxyadenosine [2-CdA]) in this disease. <\/jats:p><jats:p> PATIENTS AND METHODS: Patients with histologically verified MALT-type lymphoma were enrolled. 2-CdA was administered at a dose of 0.12 mg\/kg body weight on 5 consecutive days, as a 2-hour infusion. Cycles were repeated every 4 weeks for a maximum of six cycles. <\/jats:p><jats:p> RESULTS: Nineteen patients with gastric and seven patients with extragastric MALT lymphoma were enrolled. All patients were chemotherapy-naive, and two had been locally irradiated before systemic relapse of the lymphoma. A total of 102 cycles was administered to our patients (median number of cycles per patient, four). All 25 assessable patients responded to treatment: 21 patients (84%) achieved complete remission (CR) and four patients achieved partial remission. All patients (100%) with gastric presentation, but only three patients (43%) with extragastric presentation, achieved CR. Toxicities were moderate and mainly hematologic and required dose reduction and\/or premature discontinuation of therapy in only three cases. Two patients died from vascular events, one shortly after the first cycle because of myocardial infarction and the other from stroke 3 months after the second course. Three patients relapsed after 13, 18, and 22 months and one patient showed progressive disease after 15 months. At present, 24 patients are alive at a median follow-up time of 32 months. <\/jats:p><jats:p> CONCLUSION: Our data demonstrate that 2-CdA is highly effective in inducing CR in 84% of patients with MALT-type lymphoma. <\/jats:p>","DOI":"10.1200\/jco.2002.05.117","type":"journal-article","created":{"date-parts":[[2002,9,12]],"date-time":"2002-09-12T17:42:13Z","timestamp":1031852533000},"page":"3872-3877","source":"Crossref","is-referenced-by-count":111,"title":["Treatment of Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type With Cladribine: A Phase II Study"],"prefix":"10.1200","volume":"20","author":[{"given":"Gerald","family":"J\u00e4ger","sequence":"first","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. Veit, Department of Hematology and Oncology, General Hospital Salzburg, Salzburg, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Neumeister","sequence":"additional","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. Veit, Department of Hematology and Oncology, General Hospital Salzburg, Salzburg, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Brezinschek","sequence":"additional","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. Veit, Department of Hematology and Oncology, General Hospital Salzburg, Salzburg, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hinterleitner","sequence":"additional","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. Veit, Department of Hematology and Oncology, General Hospital Salzburg, Salzburg, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Fiebiger","sequence":"additional","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. Veit, Department of Hematology and Oncology, General Hospital Salzburg, Salzburg, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melitta","family":"Penz","sequence":"additional","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. Veit, Department of Hematology and Oncology, General Hospital Salzburg, Salzburg, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J.","family":"Neumann","sequence":"additional","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. Veit, Department of Hematology and Oncology, General Hospital Salzburg, Salzburg, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Mlineritsch","sequence":"additional","affiliation":[{"name":"From the Division of Hematology, Division of Gastroenterology, Institute of Medical Informatics, Statistics and Documentation and Institute of Pathology, Karl-Franzens University of Graz, Graz; Departments of Internal Medicine I, Division of Oncology and Division of Clinical Pathology, University of Vienna, and 3.Med Division, Kaiser Franz Josef-Spital, Vienna; and Internal Medicine S. 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