{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:42:59Z","timestamp":1773078179115,"version":"3.50.1"},"reference-count":42,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:p> PURPOSE: Non-Hodgkin\u2019s lymphoma (NHL) arising in bone is a heterogeneous histologic type of NHL that includes large-cell lymphoma, lymphoblastic lymphoma, and small noncleaved-cell lymphoma. NHL arising in bone is well recognized in adults but is less well characterized and infrequent in children and adolescents. <\/jats:p><jats:p> PATIENTS AND METHODS: We performed a retrospective review of Children\u2019s Cancer Group (CCG) studies treating children and adolescents with NHL over a 20-year period (CCG-551, CCG-501, CCG-502, CCG-503, CCG-552, CCG-5911, and CCG-5941) and determined the response and event-free survival (EFS) rates in 31 patients with NHL arising in bone. <\/jats:p><jats:p> RESULTS: The patients ranged in age from 3 to 17 years (median, 11 years; mean, 11 years), and 64.5% were male. All 31 (100%) patients achieved complete response. For 31 patients with NHL arising in bone, the product-limit estimated 5-year EFS was 83.8% \u00b1 6.7%. EFS in 17 patients with localized disease (Murphy stages I and II) was 94.1% \u00b1 5.7%, and EFS in 14 patients with disseminated disease (Murphy stage III) was 70.7% \u00b1 12.4% (log-rank P = .10). EFS in 17 patients treated with chemotherapy and radiation was 70.1% \u00b1 11.2%, and EFS in 14 patients treated with chemotherapy without radiation was 100% (P = .03). EFS in 26 patients with histology-directed treatment (LSA2-L2 or ADCOMP for lymphoblastic, other therapy for nonlymphoblastic) was 92.2% \u00b1 5.3%, and in five patients with nonhistology-directed treatment it was 40.0% \u00b1 21.9% (P &lt; .001). <\/jats:p><jats:p> CONCLUSION: NHL arising in bone is a heterogeneous type of NHL that makes up approximately 2.0% of NHL in children and adolescents on CCG studies. Response and survival in this young age group seem superb, with histology-directed treatment protocols without radiation in both localized and disseminated disease. <\/jats:p>","DOI":"10.1200\/jco.2002.06.017","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:13:48Z","timestamp":1027775628000},"page":"2293-2301","source":"Crossref","is-referenced-by-count":53,"title":["Non-Hodgkin\u2019s Lymphoma Arising in Bone in Children and Adolescents Is Associated With an Excellent Outcome: A Children\u2019s Cancer Group Report"],"prefix":"10.1200","volume":"20","author":[{"given":"Mark A.","family":"Lones","sequence":"first","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sposto","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall E.","family":"Kadin","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl R.","family":"Kjeldsberg","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Wilson","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Zwick","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; and Division of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell S.","family":"Cairo","sequence":"additional","affiliation":[{"name":"From the Pathology Department, Children\u2019s Hospital of Orange County\/St Joseph Hospital, Orange, CA; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT; Operations Center, Children\u2019s Oncology Group, Arcadia, CA; Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pathology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA; Pathology Department, Children\u2019s Mercy Hospital, Kansas City, MO; 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